Results 81 to 90 of about 3,113 (145)

Bundle structures inside the deep cervical lymphatic vessels of mice

Scientific Reports
The lymphatic system plays a crucial role in immune function and the removal of cellular waste. Recent studies have highlighted the presence of primo vessels (PVs) inside lymphatic vessels, distinct from conventional lymphatic tissues, yet their ...
Joonyoung Shin, Sungchul Kim
doaj   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage

Journal of Neuroinflammation
Background Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disorder primarily caused by the rupture of aneurysm, which results in a high mortality rate and consequently imposes a significant burden on society. The occurrence of SAH initiates an
Dandan Gao, Bin Zou, Kunyuan Zhu, Shijun Bi, Wenxu Zhang, Xinyu Yang, Jieyu Lai, Guobiao Liang, Pengyu Pan   +8 more
doaj   +1 more source

Age‐Associated B Cells: Origins, Regulation, and Tissue‐Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a distinct B cell population characterized by coexpression of T‐bet and CD11c. First described in aged female mice and autoimmune‐prone strains, ABCs are now recognized to be associated with multiple human autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis,
Kira Rubtsova
wiley   +1 more source

Role of meningeal lymphatic vessels in brain homeostasis

Frontiers in Immunology
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Meng-Ying Zhao, Chao-Yuan Ye, Yuan-Cheng Liu, Xiao-Ming Wang, Jun-Cai Fu, Xin-Yuan Liu, Rui Zhu, Yi-Zhao Li, Qing Tian   +8 more
openaire   +3 more sources

Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice

Journal of Neuroinflammation
Background Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction caused by sepsis. Neuroinflammation induced by sepsis is considered a potential mechanism of SAE; however, very little is known about the role of the meningeal lymphatic ...
Hongquan Dong, Xiaonan Dai, Yin Zhou, Chonglong Shi, Piplu Bhuiyan, Zhaochu Sun, Nana Li, Wenjie Jin   +7 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 7, Page 1433-1442, July 2026.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders

Plastic and Reconstructive Surgery, Global Open
Background:. The central nervous system (CNS) was long believed to be devoid of lymphatic drainage. However, the discovery of the glymphatic system and meningeal lymphatics has revolutionized our understanding of cerebrospinal fluid homeostasis and ...
Jennifer A. Watson, MD, Samuel Knoedler, MD, Donata von Reibnitz, MD, Carmen E. Zurfluh, MD, Carlotta Imholz, MMed, Giuseppe Esposito, MD, PhD, Simon J. Schreiner, MD, Epameinondas Gousopoulos, MD, PhD, Aijia Cai, MD, Sedef Kollarik, PhD, Pietro Giovanoli, MD, Christian Baumann, MD, Nicole Lindenblatt, MD   +12 more
doaj   +1 more source