Results 81 to 90 of about 3,252 (154)

Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage

Journal of Neuroinflammation
Background Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disorder primarily caused by the rupture of aneurysm, which results in a high mortality rate and consequently imposes a significant burden on society. The occurrence of SAH initiates an
Dandan Gao, Bin Zou, Kunyuan Zhu, Shijun Bi, Wenxu Zhang, Xinyu Yang, Jieyu Lai, Guobiao Liang, Pengyu Pan   +8 more
doaj   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, Volume 13, Issue 52, 18 September 2026.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice

Journal of Neuroinflammation
Background Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction caused by sepsis. Neuroinflammation induced by sepsis is considered a potential mechanism of SAE; however, very little is known about the role of the meningeal lymphatic ...
Hongquan Dong, Xiaonan Dai, Yin Zhou, Chonglong Shi, Piplu Bhuiyan, Zhaochu Sun, Nana Li, Wenjie Jin   +7 more
doaj   +1 more source

Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders

Plastic and Reconstructive Surgery, Global Open
Background:. The central nervous system (CNS) was long believed to be devoid of lymphatic drainage. However, the discovery of the glymphatic system and meningeal lymphatics has revolutionized our understanding of cerebrospinal fluid homeostasis and ...
Jennifer A. Watson, MD, Samuel Knoedler, MD, Donata von Reibnitz, MD, Carmen E. Zurfluh, MD, Carlotta Imholz, MMed, Giuseppe Esposito, MD, PhD, Simon J. Schreiner, MD, Epameinondas Gousopoulos, MD, PhD, Aijia Cai, MD, Sedef Kollarik, PhD, Pietro Giovanoli, MD, Christian Baumann, MD, Nicole Lindenblatt, MD   +12 more
doaj   +1 more source

Meningeal lymphatic-associated brain swelling in acute stroke

PLOS One
Brain meninges contain lymphatic vessels that play roles in clearance of extracellular solute in the central nervous system. But, whether and how the system is involved in acute stroke remains to be fully explored. Here, we show the VEGF-C-Flt4 pathway involvement in brain swelling in acute phase of ischemic stroke in rats.
Rohan Mahesh Patil, Dong Bin Back, Gen Hamanaka, Rakhi Desai, Ayumi Hayakawa, Su Jing Chan, Bum Ju Ahn, Giuseppe Pignataro, Kazuhide Hayakawa, Elga Esposito   +9 more
openaire   +2 more sources

A preliminary study on the effect of quantified cranial osteopathic manipulation on wild-type and transgenic rat models of Alzheimer's disease

Journal of Alzheimer's Disease Reports
Alzheimer's disease is a chronic progressive neurodegenerative disorder that impairs the meningeal lymphatics, glymphatic system, and compartmental fluid exchange, leading to a decline in cognitive function.
De’Yana Hines, Hope Tobey, Patrick Dugan, Seth Boehringer, Richard Helm, Ramu Anandakrishnan, Stephen Werre, Pamela VandeVord, Blaise M Costa   +8 more
doaj   +1 more source

Draining the Brain: A Novel Noninvasive Lymphatic Therapy for Parkinson’s Disease

Lymphatics
The discovery of the glymphatic system and meningeal lymphatic vessels established that the brain possesses an organized lymphatic clearance network that drains to the deep cervical lymphatics.
Yazan Mahafza, Winnie Pao, Angela Bialorucki, Heidi Simon, Wei F. Chen   +4 more
doaj   +1 more source

Meningeal lymphatic dysfunction mediates postoperative sleep deprivation-induced cognitive decline via impaired neuroinflammatory clearance

Journal of Neuroinflammation
Postoperative sleep deprivation (PSD) exacerbates perioperative neurocognitive disorders (PND) through unresolved neuroinflammation, yet the underlying mechanisms remain elusive.
Binkang Huang, Wei Tu, Han Zhou, Lan Mo, Qiubo Yang, Yilong Sheng, Daofan Sun, Bo Meng, Zhexi Chi, Yingying Lv, Rongjun Liu, Xiuzhong Xing, Hui Yuan, Jing Yang, Fengdeng Hu, Guo Chen, Junping Chen, Xiaowei Chen, Bo Lu   +18 more
doaj   +1 more source

Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness: the role of the meningeal lymphatics. [PDF]

Front Optoelectron, 2023
Oxana SG, Alexander S, Inna B, Ivan F, Andrey T, Alexander D, Maria T, Daria E, Viktoria A, Arina E, Valeria T, Anna T, Valeria K, Maria M, Alexander D, Thomas P, Jürgen K.   +16 more
europepmc   +1 more source