Results 91 to 100 of about 3,212 (171)

Coupling between global brain blood oxygen level‐dependent activity and cerebrospinal fluid dynamics in young endurance athletes

Experimental Physiology, EarlyView.
Abstract Cerebrospinal fluid (CSF) contributes to brain waste clearance through its coupling with cerebral haemodynamics. Aerobic exercise promotes brain health, but its influence on brain waste clearance remains unclear. This study examined the coupling between CSF and cerebral haemodynamics in endurance athletes. Fifteen young male endurance athletes
Daisuke Hoshi, Marina Fukuie, Ryota Asahara, Tsubasa Tomoto, David C. Zhu, Rong Zhang, Keigo Ohyama‐Byun, Seiji Maeda, Jun Sugawara, Takashi Tarumi   +9 more
wiley   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Bundle structures inside the deep cervical lymphatic vessels of mice

Scientific Reports
The lymphatic system plays a crucial role in immune function and the removal of cellular waste. Recent studies have highlighted the presence of primo vessels (PVs) inside lymphatic vessels, distinct from conventional lymphatic tissues, yet their ...
Joonyoung Shin, Sungchul Kim
doaj   +1 more source

Role of meningeal lymphatic vessels in brain homeostasis

Frontiers in Immunology
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Meng-Ying Zhao, Chao-Yuan Ye, Yuan-Cheng Liu, Xiao-Ming Wang, Jun-Cai Fu, Xin-Yuan Liu, Rui Zhu, Yi-Zhao Li, Qing Tian   +8 more
openaire   +3 more sources

Optical coherent tomography and fluorescent microscopy for the study of meningeal lymphatic systems

, 2018
The development of novel technologies for the imaging of meningeal lymphatic vessels is one of the amazing trends of biophotonics thanks to discovery of brain lymphatics over several years ago.
Abdurashitov, Arkady S., Shareef, Ali Ismat, V. Tuchin, Sindeeva, Olga A., Semyachkina-Glushkovskaya, Oxana V., M. Ulanova, M. Dvoryatkina, Oxana V. Semyachkina-Glushkovskaya, Ulanova, Mariya V., Karavaev, A., A. Pavlov, O. Sindeeva, I. Agranovich, E. Saranceva, A. Shirokov, Namykin, Anton A., Khorovodov, Alexander P., Saranceva, Elena, Shushunova, Natalia A., A. Abdurashitov, A. Namykin, A. Karavaev, Pavlov, Alexey, A. Khorovodov, Agranovich, Ilana, Bodrova, Anastasia A., I. Fedosov, Fedosov, Ivan V., N. Shushunova, Sagatova, Madina M., Dvoryatkina, M., M. Sagatova, Ali Esmat Shareef, Tuchin, Valery V., Shirokov, Alexander, A. Bodrova   +35 more
core   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage

Journal of Neuroinflammation
Background Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disorder primarily caused by the rupture of aneurysm, which results in a high mortality rate and consequently imposes a significant burden on society. The occurrence of SAH initiates an
Dandan Gao, Bin Zou, Kunyuan Zhu, Shijun Bi, Wenxu Zhang, Xinyu Yang, Jieyu Lai, Guobiao Liang, Pengyu Pan   +8 more
doaj   +1 more source

Characterizing Intracranial Lymphatic Development in Zebrafish

, 2020
The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain.
Bakary Samasa (8722090), Van N. Pham (8722114), Daniel Castranova (8722097), Hyun Min Jung (2323360), Marina Venero Galanternik (8722112), Brant M Weinstein (37722)   +5 more
core   +1 more source

Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Neurotoxic protein accumulation is widely recognized as a key feature of Alzheimer's disease (AD), and increasing evidence indicates that impaired brain clearance associated with dysfunction of the meningeal lymphatic and glymphatic may contribute to this process.
Jiheng Zhang, Jiren Zhang, Jian Ding, Xian Zhang, Yuhua Wang, Wei Wei, Yan Chai, Shu Zhang, Xin Chen   +8 more
wiley   +1 more source