Results 91 to 100 of about 3,113 (145)

A preliminary study on the effect of quantified cranial osteopathic manipulation on wild-type and transgenic rat models of Alzheimer's disease

Journal of Alzheimer's Disease Reports
Alzheimer's disease is a chronic progressive neurodegenerative disorder that impairs the meningeal lymphatics, glymphatic system, and compartmental fluid exchange, leading to a decline in cognitive function.
De’Yana Hines, Hope Tobey, Patrick Dugan, Seth Boehringer, Richard Helm, Ramu Anandakrishnan, Stephen Werre, Pamela VandeVord, Blaise M Costa   +8 more
doaj   +1 more source

Meningeal lymphatic-associated brain swelling in acute stroke

PLOS One
Brain meninges contain lymphatic vessels that play roles in clearance of extracellular solute in the central nervous system. But, whether and how the system is involved in acute stroke remains to be fully explored. Here, we show the VEGF-C-Flt4 pathway involvement in brain swelling in acute phase of ischemic stroke in rats.
Rohan Mahesh Patil, Dong Bin Back, Gen Hamanaka, Rakhi Desai, Ayumi Hayakawa, Su Jing Chan, Bum Ju Ahn, Giuseppe Pignataro, Kazuhide Hayakawa, Elga Esposito   +9 more
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Meningeal lymphatic dysfunction mediates postoperative sleep deprivation-induced cognitive decline via impaired neuroinflammatory clearance

Journal of Neuroinflammation
Postoperative sleep deprivation (PSD) exacerbates perioperative neurocognitive disorders (PND) through unresolved neuroinflammation, yet the underlying mechanisms remain elusive.
Binkang Huang, Wei Tu, Han Zhou, Lan Mo, Qiubo Yang, Yilong Sheng, Daofan Sun, Bo Meng, Zhexi Chi, Yingying Lv, Rongjun Liu, Xiuzhong Xing, Hui Yuan, Jing Yang, Fengdeng Hu, Guo Chen, Junping Chen, Xiaowei Chen, Bo Lu   +18 more
doaj   +1 more source

Neurosurgery as an immune anchor point: a translational framework for perioperative immunoengineering

Frontiers in Immunology
Neurosurgical diseases—including brain tumors, hemorrhage/trauma, ischemia, infection, epilepsy, and spinal cord injury—share convergent neuro-immune mechanisms.
Zheng Hu, Zheng Hu, Jun Luo, Jun Luo, Jianyun Lou, Jianyun Lou, Juntao Deng, Juntao Deng, Zi tao Gong, Jinming Chen, Jinming Chen   +10 more
doaj   +1 more source

Beyond AQP-4: convergent glymphatic-meningeal lymphatic dysfunction underlying multifactorial migraine pathogenesis

Frontiers in Immunology
The glymphatic system (GS) functions as a critical pathway for waste clearance from the brain, facilitating soluble protein and metabolite drainage. Recently, GS dysfunction has emerged as a potential contributor to migraine pathophysiology.
Meng-fan Yang, Meng-fan Yang, Mao-mei Song, Ying-jie Gao, Ting-yan Chen, Sui-yi Xu, Sui-yi Xu   +6 more
doaj   +1 more source

Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin

Scientific Reports
In humans and mice, the glymphatic system, critical for central nervous system (CNS) health, relies on cardiorespiratory coupling, but has not yet been investigated in a diving mammal that routinely experiences apnea, bradycardia, and peripheral vasoconstriction.
Pabst, D. Ann, Keenan, Tiffany F., Braun, Molly, Tift, Michael S., Rotstein, David S., Caron, Kathleen M., McLellan, William A., Rommel, Sentiel A., Jackson, Olivia N., Kernagis, Dawn N., Costidis, Alexander M., Nelson-Maney, Nathan P.   +11 more
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A Review on The Glymphatic System and Meningeal Lymphatics

International Journal of Medical Science and Dental Health
The maintenance of neuronal homeostasis within the central nervous system (CNS) requires the efficient removal of metabolic waste products and neurotoxic proteins. Historically, the CNS was considered devoid of a conventional lymphatic system, relying solely on passive diffusion for solute clearance. This paradigm shifted with the identification of the
openaire   +1 more source

Impaired meningeal lymphatic drainage in Listeria monocytogenes infection

Frontiers in Immunology
Previous studies have demonstrated an association between lymphatic vessels and diseases caused by bacterial infections. Listeria monocytogenes (LM) bacterial infection can affect multiple organs, including the intestine, brain, liver and spleen, which can be fatal.
Jian Feng, Yuanzhen Ren, Xilin Wang, Xilin Wang, Xiaojing Li, Xingguo Zhu, Baokai Zhang, Baokai Zhang, Qi Zhao, Xiaochen Sun, Xinxin Tian, Hongyang Liu, Fan Dong, Xiu-Li Li, Linlin Qi, Bin Wei, Bin Wei   +16 more
openaire   +3 more sources

Meningeal lymphatics in aging and Alzheimer’s disease [PDF]

Nature Medicine, 2018
openaire   +2 more sources

Assessment of Meningeal Lymphatics in the Parasagittal Dural Space: A Prospective Feasibility Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging. [PDF]

Korean J Radiol, 2023
Joo B, Park M, Ahn SJ, Suh SH.
europepmc   +1 more source