Results 101 to 110 of about 3,212 (171)

Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice

Journal of Neuroinflammation
Background Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction caused by sepsis. Neuroinflammation induced by sepsis is considered a potential mechanism of SAE; however, very little is known about the role of the meningeal lymphatic ...
Hongquan Dong, Xiaonan Dai, Yin Zhou, Chonglong Shi, Piplu Bhuiyan, Zhaochu Sun, Nana Li, Wenjie Jin   +7 more
doaj   +1 more source

Circulatory pro‐CTSD binds brain endothelial LRP1 to trigger its lysosomal degradation leading to amyloid beta clearance deficit in Alzheimer's disease mice

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Clearance of cerebral Aβ was primarily mediated by the brain endothelial transporters including LRP1. The regulatory mechanism of LRP1 expression remained unclear. METHODS LRP1 in brain endothelial cells treated with pro‐CTSD were analyzed by western blot.
Zhi‐Jun Li, Zhao Yang, Dan Zhao, Yi‐Hua Qiu, Wen‐Yu Wan, Zeng‐Kang Huang, Li Tian, Rui‐Qun Qi, Hong‐Guang Liu, Yu‐Hua Chen, Dong‐Yu Min, Xiao‐Qian Xu, Wei‐Dong Zhao   +12 more
wiley   +1 more source

Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders

Plastic and Reconstructive Surgery, Global Open
Background:. The central nervous system (CNS) was long believed to be devoid of lymphatic drainage. However, the discovery of the glymphatic system and meningeal lymphatics has revolutionized our understanding of cerebrospinal fluid homeostasis and ...
Jennifer A. Watson, MD, Samuel Knoedler, MD, Donata von Reibnitz, MD, Carmen E. Zurfluh, MD, Carlotta Imholz, MMed, Giuseppe Esposito, MD, PhD, Simon J. Schreiner, MD, Epameinondas Gousopoulos, MD, PhD, Aijia Cai, MD, Sedef Kollarik, PhD, Pietro Giovanoli, MD, Christian Baumann, MD, Nicole Lindenblatt, MD   +12 more
doaj   +1 more source

Our Current Understanding of the Lymphatics of the Brain and Spinal Cord.

, 2018
The lymphatic system, segregated from the blood vascular system, is an essential anatomical route along which interstitial fluid, solutes, lipids, immune cells, and cellular debris, are conveyed.
Schmidt, Cameron, Macchi, Veronica, Tubbs, R Shane, De Caro, Raffaele, Yilmaz, Emre, Dupont, Graham, Oskouian, Rod J   +6 more
core  

Advances and controversies in meningeal biology [PDF]

The dura, arachnoid and pia mater, as the constituent layers of the meninges, along with cerebrospinal fluid in the subarachnoid space and ventricles, are essential protectors of the brain and spinal cord.
Koh, Gou Young, Proulx, Steven T, Betsholtz, Christer,, Siegenthaler, Julie,, Betsholtz, Christer, Koh, Gou Young,, Engelhardt, Britta, Proulx, Steven T.,, Siegenthaler, Julie, Mcdonald, Donald M.,, McDonald, Donald M, Engelhardt, Britta,   +11 more
core   +1 more source

A preliminary study on the effect of quantified cranial osteopathic manipulation on wild-type and transgenic rat models of Alzheimer's disease

Journal of Alzheimer's Disease Reports
Alzheimer's disease is a chronic progressive neurodegenerative disorder that impairs the meningeal lymphatics, glymphatic system, and compartmental fluid exchange, leading to a decline in cognitive function.
De’Yana Hines, Hope Tobey, Patrick Dugan, Seth Boehringer, Richard Helm, Ramu Anandakrishnan, Stephen Werre, Pamela VandeVord, Blaise M Costa   +8 more
doaj   +1 more source

Connections Between Amyloid Beta and the Meningeal Lymphatics As a Possible Route for Clearance and Therapeutics.

, 2019
Alzheimer\u27s disease (AD) is a complex neurodegenerative disorder causing progressive cognitive decline, memory loss, and death of neural tissue. Current research suggests a connection between bulk flow of interstitial fluid and cerebrospinal fluid ...
Iwanaga, Joe, Tubbs, R Shane, Yilmaz, Emre, Dupont, Graham   +3 more
core  

Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination

The precise neurophysiological changes prompted by meningeal lymphatic dysfunction remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in ...
Makuch, Mateusz, Faroqi, Ayman H, das Neves, Sofia P, Da Mesquita, Sandro, Barber, Megan J, Thomas, Jean-Leon, Almeida, Francisco, Rego, Shanon, Piehl, Fredrik, Sanchez, Guadalupe, Schrader, Racquelle, Delivanoglou, Nickoleta, McLean, Pamela J, Cucuzza, Chiara Starvaggi, Irani, Sarosh R, Oliveira, Tiago Gil, Ren, Yingxue   +16 more
core   +1 more source

Meningeal lymphatic-associated brain swelling in acute stroke. [PDF]

PLoS One
Brain meninges contain lymphatic vessels that play roles in clearance of extracellular solute in the central nervous system. But, whether and how the system is involved in acute stroke remains to be fully explored. Here, we show the VEGF-C-Flt4 pathway involvement in brain swelling in acute phase of ischemic stroke in rats.
Patil RM, Back DB, Hamanaka G, Desai R, Hayakawa A, Chan SJ, Ahn BJ, Pignataro G, Hayakawa K, Esposito E.   +9 more
europepmc   +3 more sources

New insights into phototherapy of glioblastoma: the meningeal lymphatics and sleep

The meningeal lymphatics (MLVs) play an important role in immunity and maintaining homeostasis of the central nervous system. Sleep is a natural state when lymphatic drainage becomes maximally active and, along with the flow of fluids, toxins and ...
Viktoria Adushkina, Daria Zlatogosrkaya, Inna Blokhina, Alexander Shirokov, Valeria Telnova, Andrey Terskov, Egor Ilukov   +6 more
core   +1 more source