Results 51 to 60 of about 3,252 (154)

The C–C chemokine receptor 7: An immune molecule that modulates central nervous system function in homeostasis and disease

Brain, Behavior, & Immunity - Health, 2023
The interaction between the central nervous system (CNS) and the peripheral immune system is key for brain function in homeostasis and disease. Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells ...
Gisel Flores-Montoya, Daniel Quintero, Devavani Chatterjea, Hannah Uttley, Colin Liphart, Zichen Tian, Elliot Yim, Fengping Hu   +7 more
doaj   +1 more source

Epistemological Anatomy: A Conceptual Framework for Understanding Anatomical Knowledge

Clinical Anatomy, EarlyView.
ABSTRACT Anatomy is often regarded as settled knowledge. Yet anatomical propositions differ enormously in their evidentiary foundations, while textbooks and atlases frequently present them with similar certainty. How, then, does an anatomical observation become anatomical knowledge? We introduce epistemological anatomy as a framework for the systematic
Marios Loukas, Joe Iwanaga, Mi‐Sun Hur, Seiichi Inoue, Mohammed K. Khalil, R. Shane Tubbs   +5 more
wiley   +1 more source

Mapping meningeal vasculature in non-human primates

Veins and Lymphatics, 2022
Background. The blood-brain barrier has been the focus of most prior work examining intracranial vasculature in the context of various brain diseases.1 Recently, meningeal vasculature has become more widely recognized as a key contributor to brain ...
Christopher Janson, Kyle Hauser, Scott Muller, Jeffrey H. Kordower, Liudmila Romanova   +4 more
doaj   +1 more source

Conserved meningeal lymphatic drainage circuits in mice and humans

Journal of Experimental Medicine, 2022
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of the dura mater, where they ensure waste product elimination and immune surveillance of brain tissues. Whether MLVs exist in the anterior part of the murine and human skull and how they connect with the glymphatic system and extracranial lymphatics remained ...
Jacob, Laurent, de Brito Neto, Jose, Lenck, Stephanie, Corcy, Celine, Benbelkacem, Farhat, Geraldo, Luiz Henrique, Xu, Yunling, Thomas, Jean-Mickael, El Kamouh, Marie-Renee, Spajer, Myriam, Potier, Marie-Claude, Haik, Stephane, Kalamarides, Michel, Stankoff, Bruno, Lehericy, Stephane, Eichmann, Anne, Thomas, Jean-Leon   +16 more
openaire   +2 more sources

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Nature Communications, 2022
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral
Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile, Onder Albayram   +6 more
doaj   +1 more source

CSF circulation and dispersion yield rapid clearance from intracranial compartments

Frontiers in Bioengineering and Biotechnology, 2022
In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles.
Martin Hornkjøl, Lars Magnus Valnes, Geir Ringstad, Geir Ringstad, Marie E. Rognes, Marie E. Rognes, Per-Kristian Eide, Per-Kristian Eide, Kent-André Mardal, Kent-André Mardal, Vegard Vinje   +10 more
doaj   +1 more source

Phase coupling between eye and brain pulsations is bidirectional and modulated by the parasympathetic system – An fMREye study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Physiological pulsations driven by cardiac, respiratory, and vasomotor activity are essential for solute transport within perivascular and perineural cerebrospinal fluid (CSF) pathways that support brain and eye clearance systems. Previous studies have shown that parasympathetic blockade significantly reduces ocular pulsation power and
Ebrahimi Seyed‐Mohsen, Väyrynen Tommi, Huotari Niko, Saarela Ville, Honkamo Marja, Helakari Heta, Järvelä Matti, Korhonen Vesa, Raitamaa Lauri, Kiviniemi Vesa   +9 more
wiley   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

Frontiers in Physiology, 2019
The contribution of cranial dura mater vascular networks, as means for maintaining brain fluid movement and balance, and as the source of significant initiators and/or contributors to neurological disorders, has been overlooked. These networks consist of
Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Virginia H. Huxley, Virginia H. Huxley, Virginia H. Huxley, Leike Xie, Filiz Bunyak, Kannappan Palaniappan, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky   +13 more
doaj   +1 more source