Results 51 to 60 of about 3,113 (145)

Fluid dynamics in aging-related dementias

Neurobiology of Disease, 2023
Recent human and animal model experimental studies revealed novel pathways for fluid movement, immune cell trafficking and metabolic waste clearance in CNS.
Thierno M. Bah, Dominic A. Siler, Aseel H. Ibrahim, Justin S. Cetas, Nabil J. Alkayed   +4 more
doaj   +1 more source

The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans

Frontiers in Physiology, 2022
The human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper ...
Neel H. Mehta, Jonah Sherbansky, Angela R. Kamer, Roxana O. Carare, Tracy Butler, Henry Rusinek, Gloria C. Chiang, Yi Li, Sara Strauss, L. A. Saint-Louis, Neil D. Theise, Richard A. Suss, Kaj Blennow, Michael Kaplitt, Mony J. de Leon   +14 more
doaj   +1 more source

The C–C chemokine receptor 7: An immune molecule that modulates central nervous system function in homeostasis and disease

Brain, Behavior, & Immunity - Health, 2023
The interaction between the central nervous system (CNS) and the peripheral immune system is key for brain function in homeostasis and disease. Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells ...
Gisel Flores-Montoya, Daniel Quintero, Devavani Chatterjea, Hannah Uttley, Colin Liphart, Zichen Tian, Elliot Yim, Fengping Hu   +7 more
doaj   +1 more source

Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node

Frontiers in Immunology, 2018
A hallmark feature of follicular dendritic cells (FDCs) within the lymph nodes (LNs) is their ability to retain antigens and virions for a prolonged duration.
Rajnish S. Dave, Pooja Jain, Siddappa N. Byrareddy   +2 more
doaj   +1 more source

Mapping meningeal vasculature in non-human primates

Veins and Lymphatics, 2022
Background. The blood-brain barrier has been the focus of most prior work examining intracranial vasculature in the context of various brain diseases.1 Recently, meningeal vasculature has become more widely recognized as a key contributor to brain ...
Christopher Janson, Kyle Hauser, Scott Muller, Jeffrey H. Kordower, Liudmila Romanova   +4 more
doaj   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Conserved meningeal lymphatic drainage circuits in mice and humans

Journal of Experimental Medicine, 2022
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of the dura mater, where they ensure waste product elimination and immune surveillance of brain tissues. Whether MLVs exist in the anterior part of the murine and human skull and how they connect with the glymphatic system and extracranial lymphatics remained ...
Jacob, Laurent, de Brito Neto, Jose, Lenck, Stephanie, Corcy, Celine, Benbelkacem, Farhat, Geraldo, Luiz Henrique, Xu, Yunling, Thomas, Jean-Mickael, El Kamouh, Marie-Renee, Spajer, Myriam, Potier, Marie-Claude, Haik, Stephane, Kalamarides, Michel, Stankoff, Bruno, Lehericy, Stephane, Eichmann, Anne, Thomas, Jean-Leon   +16 more
openaire   +2 more sources

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
doaj   +1 more source

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Nature Communications, 2022
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral
Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile, Onder Albayram   +6 more
doaj   +1 more source

Arterial Perivascular Space‐Mediated Solute Transport in the Mouse Brain

Exploration, EarlyView.
The mechanisms underlying solute clearance from the brain parenchyma remain debated, with competing hypotheses involving bulk cerebrospinal fluid flow versus perivascular transport. Using multimodal in vivo imaging and computational modeling in mice, this study demonstrates that arterial pulsation drives bidirectional solute movement within the ...
Shiyong Li, Ye Wang, Guangyu Jia, Yamei Yu, Zhe Zhang, Qi Wang, Kaelyn V. Becker, Jonathan W. Engle, Dawei Jiang, Weibo Cai   +9 more
wiley   +1 more source