Results 31 to 40 of about 3,113 (145)

Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS

Frontiers in Immunology, 2023
In recent decades there has been a large focus on understanding the mechanisms of peripheral immune cell infiltration into the central nervous system (CNS) in neuroinflammatory diseases.
Collin Laaker, Cameron Baenen, Kristóf G. Kovács, Matyas Sandor, Zsuzsanna Fabry   +4 more
doaj   +1 more source

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels

Frontiers in Immunology, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint, László Bálint, Zsombor Ocskay, Zsombor Ocskay, Bálint András Deák, Bálint András Deák, Petra Aradi, Petra Aradi, Zoltán Jakus, Zoltán Jakus   +9 more
doaj   +1 more source

Meningeal lymphatics can influence stroke outcome. [PDF]

J Exp Med
Meningeal lymphatics are conduits for cerebrospinal fluid drainage to lymphatics and lymph nodes in the neck. In this issue of JEM, Boisserand et al. (https://doi.org/10.1084/jem.20221983) provide evidence that expansion of meningeal lymphatics protects against ischemic stroke.
Koh GY, McDonald DM.
europepmc   +5 more sources

Abstract 1122‐000183: Assessing Meningeal Lymphatic MRI Biomarkers in Acute Large Vessel Occlusion Stroke Treated with Thrombectomy

Stroke: Vascular and Interventional Neurology, 2021
Introduction: Until recently, there was very little known about the brain’s waste removal system. Unlike the peripheral organ systems, the CNS lacked a clearly defined lymphatic vasculature and waste clearance mechanism.
Richard Pham, Rano Chatterjee
doaj   +1 more source

Development and plasticity of meningeal lymphatic vessels [PDF]

Journal of Experimental Medicine, 2017
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance. We show here that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along
Aspelund Aleksanteri, Nurmi Harri, Alitalo Kari, Saarma Mart, Voutilainen Merja H., Airavaara Mikko, Antila Salli, Fang Shentong, Karaman Sinem, Li Zhilin, Aspelund Aleksanteri, Nurmi Harri, Alitalo Kari, Saarma Mart, Voutilainen Merja H., Airavaara Mikko, Antila Salli, Fang Shentong, Karaman Sinem, Li Zhilin   +19 more
openaire   +3 more sources

The cervical lymph node contributes to peripheral inflammation related to Parkinson’s disease

Journal of Neuroinflammation, 2023
Background Peripheral inflammation is an important feature of Parkinson’s disease (PD). However, if and how CNS pathology is involved in the peripheral inflammation in PD remains to be fully investigated.
Zongran Liu, Yang Huang, Xuejing Wang, Jia-Yi Li, Can Zhang, Ying Yang, Jing Zhang   +6 more
doaj   +1 more source

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature [PDF]

Nature Neuroscience, 2018
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link between the CNS and peripheral ...
Antoine Louveau, Jasmin Herz, Maria Nordheim Alme, Andrea Francesca Salvador, Michael Q. Dong, Kenneth E. Viar, S. Grace Herod, James Knopp, Joshua C. Setliff, Alexander L. Lupi, Sandro Da Mesquita, Elizabeth L. Frost, Alban Gaultier, Tajie H. Harris, Rui Cao, Song Hu, John R. Lukens, Igor Smirnov, Christopher C. Overall, Guillermo Oliver, Jonathan Kipnis   +20 more
openaire   +2 more sources

Charting the meningeal lymphatic network

Journal of Experimental Medicine, 2022
A genuine network of lymphatic vessels can be found in the dural layer of the meninges that ensheathe the brain and spinal cord of mammalians. In this issue, Jacob et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220035) employ light sheet fluorescence imaging of intact mouse heads to provide a more comprehensive chart of the meningeal lymphatic
openaire   +2 more sources

Postnatal development of lymphatic vasculature in the brain meninges [PDF]

Developmental Dynamics, 2018
Background: Traditionally, the central nervous system (CNS) has been viewed as an immune‐privileged environment with no lymphatic vessels. This view was partially overturned by the discovery of lymphatic vessels in the dural membrane that surrounds the brain, in contact with the interior surface of the skull.
Rebecca M. Izen, Tomoko Yamazaki, Yoko Nishinaka‐Arai, Young‐Kwon Hong, Yoh‐Suke Mukouyama   +4 more
openaire   +2 more sources

Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions [PDF]

Biomedical Optics Express, 2020
There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance.
Oxana Semyachkina-Glushkovskaya, Arkady Abdurashitov, Alexander Dubrovsky, Maria Klimova, Ilana Agranovich, Andrey Terskov, Alexander Shirokov, Valeria Vinnik, Anna Kuzmina, Nikita Lezhnev, Inna Blokhina, Anastassia Shnitenkova, Valery Tuchin, Edik Rafailov, Jurgen Kurths   +14 more
openaire   +3 more sources