Results 31 to 40 of about 3,252 (154)
The cervical lymph node contributes to peripheral inflammation related to Parkinson’s disease
Journal of Neuroinflammation, 2023 Background Peripheral inflammation is an important feature of Parkinson’s disease (PD). However, if and how CNS pathology is involved in the peripheral inflammation in PD remains to be fully investigated.
Zongran Liu +6 more
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Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow. [PDF]
J Neuroimmune Pharmacol, 2018 Functional meningeal lymphatic system plays a crucial role in outflow of cerebrospinal fluid. Metabolites and neurotoxins in the cerebrospinal fluid may be excreted via this system and accumulate in the cervical lymph nodes. In this letter, we highlighted the role of functional meningeal lymphatics and cerebrospinal fluid outflow.
Dave RS, Jain P, Byrareddy SN.
europepmc +4 more sources
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature [PDF]
Nature Neuroscience, 2018 Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link between the CNS and peripheral ...
Antoine Louveau +20 more
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Charting the meningeal lymphatic network
Journal of Experimental Medicine, 2022 A genuine network of lymphatic vessels can be found in the dural layer of the meninges that ensheathe the brain and spinal cord of mammalians. In this issue, Jacob et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220035) employ light sheet fluorescence imaging of intact mouse heads to provide a more comprehensive chart of the meningeal lymphatic
openaire +2 more sources
Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions [PDF]
Biomedical Optics Express, 2020 There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance.
Oxana Semyachkina-Glushkovskaya +14 more
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Postnatal development of lymphatic vasculature in the brain meninges [PDF]
Developmental Dynamics, 2018 Background: Traditionally, the central nervous system (CNS) has been viewed as an immune‐privileged environment with no lymphatic vessels. This view was partially overturned by the discovery of lymphatic vessels in the dural membrane that surrounds the brain, in contact with the interior surface of the skull.
Rebecca M. Izen +4 more
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The growth and expansion of meningeal lymphatic networks are affected in craniosynostosis [PDF]
Development, 2021 ABSTRACT Skull malformations are associated with vascular anomalies that can impair fluid balance in the central nervous system. We previously reported that humans with craniosynostosis and mutations in TWIST1 have dural venous sinus malformations. It is still unknown whether meningeal lymphatic networks, which are patterned alongside
Phillip S. Ang +2 more
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Scientific Reports, 2022 AbstractA system of lymphatic vessels has been recently characterized in the meninges, with a postulated role in ‘cleaning’ the brain via cerebral fluid drainage. As meninges are the origin site of migraine pain, we hypothesized that malfunctioning of the lymphatic system should affect the local trigeminal nociception.
Mikhailov, Nikita +15 more
openaire +5 more sources
The Meningeal Lymphatic System: A New Player in Neurophysiology [PDF]
Neuron, 2018 The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of particular relevance is its participation in diseases associated with protein accumulation and aggregation in the brain, such as Alzheimer's disease (AD).
Sandro, Da Mesquita +2 more
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JCI Insight, 2022 The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support for routes leading to lymphatic vessels. A current debate centers upon the routes through which CSF can
Yann Decker +6 more
doaj +1 more source