Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective. [PDF]
Neurosci Insights, 2019 The recent discovery of lymphatic vessels in the meningeal layers calls into question the known mechanisms of fluid and macromolecule homeostasis and immunoregulation within the central nervous system.
Hershenhouse KS +3 more
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Role of the Meningeal Lymphatics in Stroke. [PDF]
Stroke, 2023 Perla M +3 more
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Nature Communications, 2023 Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we
Dongyu Li +18 more
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Visualising and semi-quantitatively measuring brain fluid pathways, including meningeal lymphatics, in humans using widely available MRI techniques [PDF]
Journal of Cerebral Blood Flow and Metabolism, 2023 Michael J Thrippleton +2 more
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New integrated three-interface conceptual model for clearance and immune surveillance in the human CNS. [PDF]
Front Cell Dev BiolThe central nervous system (CNS) lacks a classical lymphatic system and instead relies on cerebrospinal fluid (CSF) circulation for metabolic waste removal and for defense/immune surveillance. Recent research has consolidated the concept of an integrated
García-Cosamalón J +4 more
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The Space between the Pial Sheath and the Cortical Venous Wall May Connect to the Meningeal Lymphatics [PDF]
Magnetic Resonance in Medical Sciences, 2020 Shinji Naganawa +2 more
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Meningeal lymphatics in aging and Alzheimer's disease. [PDF]
Ann Transl Med, 2019 Recent research from the Kipnis laboratory (1-3) has highlighted the significance of meningeal lymphatics, which were originally identified in the dura mater of rat (4). These investigators underscored the crucial role of the meningeal lymphatics in brain immune surveillance and the clearance of metabolic wastes. They have also mapped out the path and
Jaffe RJ, Dave RS, Byrareddy SN.
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Meningeal lymphatics prime tumor immunity in glioblastoma. [PDF]
Cancer Cell, 2021 The notion of the brain as an immune-privileged organ has been challenged by the discovery of functional lymphatic vessels in the meninges of the dorsal and basal skull. A study published in Nature in 2020 shows that meningeal lymphatics play an important role in the sensing of brain tumor antigens.
Graham MS, Mellinghoff IK.
europepmc +3 more sources
CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
Frontiers in Pharmacology, 2021 A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves +2 more
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New insight into DAVF pathology—Clues from meningeal immunity
Frontiers in Immunology, 2022 In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape.
Tianqi Tu +8 more
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