Results 21 to 30 of about 12,817 (250)

NEW HUMAN BODY PARTS DISCOVERED

The Iraqi Journal of Medical Sciences, 2016
Reports about new discoveries in human anatomy could help in the progress of medical care in term of diagnosis and management. Among the many of these was the hidden system of vessels discovered in the human brain in 2015, the anterolateral ligament of ...
Hayder J. Mubarak
doaj   +6 more sources

Meningeal lymphatic-associated brain swelling in acute stroke. [PDF]

PLoS One
Brain meninges contain lymphatic vessels that play roles in clearance of extracellular solute in the central nervous system. But, whether and how the system is involved in acute stroke remains to be fully explored. Here, we show the VEGF-C-Flt4 pathway involvement in brain swelling in acute phase of ischemic stroke in rats.
Patil RM, Back DB, Hamanaka G, Desai R, Hayakawa A, Chan SJ, Ahn BJ, Pignataro G, Hayakawa K, Esposito E.   +9 more
europepmc   +3 more sources

Do We Swallow the Waste From Our Brain?

Frontiers in Neuroscience, 2021
Ferumoxytol, an iron oxide nanoparticle, was infused into the lateral cerebroventricle of awake rats to follow its movement and clearance from the brain using magnetic resonance imaging. Within minutes the contrast agent could be observed accumulating in
Joshua Leaston, Praveen Kulkarni, Codi Gharagouzloo, Codi Gharagouzloo, Ju Qiao, Nicole Bens, Craig F. Ferris   +6 more
doaj   +1 more source

The C–C chemokine receptor 7: An immune molecule that modulates central nervous system function in homeostasis and disease

Brain, Behavior, & Immunity - Health, 2023
The interaction between the central nervous system (CNS) and the peripheral immune system is key for brain function in homeostasis and disease. Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells ...
Gisel Flores-Montoya, Daniel Quintero, Devavani Chatterjea, Hannah Uttley, Colin Liphart, Zichen Tian, Elliot Yim, Fengping Hu   +7 more
doaj   +1 more source

Brain Glymphatic/Lymphatic Imaging by MRI and PET [PDF]

Nuclear Medicine and Molecular Imaging, 2020
Since glymphatic was proposed and meningeal lymphatic was discovered, MRI and even PET were introduced to investigate brain parenchymal interstitial fluid (ISF), cerebrospinal fluid (CSF), and lymphatic outflow in rodents and humans. Previous findings by ex vivo fluorescent microscopic, and in vivo two-photon imaging in rodents were reproduced using ...
Dong Soo, Lee, Minseok, Suh, Azmal, Sarker, Yoori, Choi   +3 more
openaire   +2 more sources

New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Anti-Inflammatory Approach

Journal of Immunology Research, 2022
Alzheimer’s is characterized by accumulation of amyloid-β (Aβ) associated with insufficient clearance of toxicants from the brain establishing a chronic inflammation and other abnormalities in the brain.
Nafiseh Pakravan, Ardeshir Abbasi, Zuhair Mohammad Hassan   +2 more
doaj   +1 more source

Postnatal development of lymphatic vasculature in the brain meninges [PDF]

Developmental Dynamics, 2018
Background: Traditionally, the central nervous system (CNS) has been viewed as an immune‐privileged environment with no lymphatic vessels. This view was partially overturned by the discovery of lymphatic vessels in the dural membrane that surrounds the brain, in contact with the interior surface of the skull.
Rebecca M. Izen, Tomoko Yamazaki, Yoko Nishinaka‐Arai, Young‐Kwon Hong, Yoh‐Suke Mukouyama   +4 more
openaire   +2 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

CSF circulation and dispersion yield rapid clearance from intracranial compartments

Frontiers in Bioengineering and Biotechnology, 2022
In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles.
Martin Hornkjøl, Lars Magnus Valnes, Geir Ringstad, Geir Ringstad, Marie E. Rognes, Marie E. Rognes, Per-Kristian Eide, Per-Kristian Eide, Kent-André Mardal, Kent-André Mardal, Vegard Vinje   +10 more
doaj   +1 more source

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Nature Communications, 2022
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral
Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile, Onder Albayram   +6 more
doaj   +1 more source