Results 21 to 30 of about 13,017 (250)

Do We Swallow the Waste From Our Brain?

Frontiers in Neuroscience, 2021
Ferumoxytol, an iron oxide nanoparticle, was infused into the lateral cerebroventricle of awake rats to follow its movement and clearance from the brain using magnetic resonance imaging. Within minutes the contrast agent could be observed accumulating in
Joshua Leaston, Praveen Kulkarni, Codi Gharagouzloo, Codi Gharagouzloo, Ju Qiao, Nicole Bens, Craig F. Ferris   +6 more
doaj   +1 more source

"Compensated hyperosmolarity" of cerebrospinal fluid and the development of hydrocephalus [PDF]

, 2013
Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure.
Vladić, Anton, Klarica, Marijan, Miše, Branko, Radoš, Milan, Orešković, Darko   +4 more
core   +1 more source

The C–C chemokine receptor 7: An immune molecule that modulates central nervous system function in homeostasis and disease

Brain, Behavior, & Immunity - Health, 2023
The interaction between the central nervous system (CNS) and the peripheral immune system is key for brain function in homeostasis and disease. Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells ...
Gisel Flores-Montoya, Daniel Quintero, Devavani Chatterjea, Hannah Uttley, Colin Liphart, Zichen Tian, Elliot Yim, Fengping Hu   +7 more
doaj   +1 more source

New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Anti-Inflammatory Approach

Journal of Immunology Research, 2022
Alzheimer’s is characterized by accumulation of amyloid-β (Aβ) associated with insufficient clearance of toxicants from the brain establishing a chronic inflammation and other abnormalities in the brain.
Nafiseh Pakravan, Ardeshir Abbasi, Zuhair Mohammad Hassan   +2 more
doaj   +1 more source

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain. [PDF]

, 2019
The relationships between cerebrospinal fluid (CSF) and brain interstitial fluid are still being elucidated. It has been proposed that CSF within the subarachnoid space will enter paravascular spaces along arteries to flush through the parenchyma of the ...
Ries, Miriam, Ries, Miriam; id_orcid, Ma, Qiaoli, Bücker, Arno, Decker, Yann, Detmar, Michael, Proulx, Steven T., Riner, Chantal, Fassbender, Klaus, Müller, Andreas   +9 more
core   +1 more source

CSF circulation and dispersion yield rapid clearance from intracranial compartments

Frontiers in Bioengineering and Biotechnology, 2022
In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles.
Martin Hornkjøl, Lars Magnus Valnes, Geir Ringstad, Geir Ringstad, Marie E. Rognes, Marie E. Rognes, Per-Kristian Eide, Per-Kristian Eide, Kent-André Mardal, Kent-André Mardal, Vegard Vinje   +10 more
doaj   +1 more source

Monitoring the cerebral venous drainage in space missions: the Drain Brain experiments of the Italian Space Agency

, 2023
It is well known that the space environment induces major alterations to various human physiological systems, determining a general deconditioning of the body. Medical research programs aim to keep the astronaut’s health status during the mission, enable
Mascetti G., Proto A., Pignataro S., Zamboni P., Menegatti E., Taibi A., Mari S., Pagani A., Valentini G.   +8 more
core   +1 more source

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Nature Communications, 2022
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral
Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile, Onder Albayram   +6 more
doaj   +1 more source

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
Jones, A., Michael P. Barrett, Peter G E Kennedy, Bradley Barbara, Bradley, Barbara, Barrett, M. P., McCabe Christopher, Peter G. E. Kennedy, Bradley, B., Rodgers, Jean, Gettinby, George, Gettinby George, Kennedy Peter G. E., McCabe, Chris, Amy Jones, Kennedy, Peter G. E., Barrett, Michael P., Michael P Barrett, Kennedy, Peter G.E., George Gettinby, Gibaud, Stephane, Barbara Bradley, McCabe, C., Mccabe, Christopher, Jean Rodgers, Kennedy, P. G. E., Gibaud, S., Stéphane Gibaud, Rodgers, J., Rodgers Jean, Jones Amy, Jones, Amy, Christopher McCabe, Barrett Michael P., Gibaud Stéphane, Gettinby, G.   +35 more
core   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source