Results 11 to 20 of about 23,235 (301)

Forgotten findings of brain lymphatics [PDF]

Nature, 2015
Éva Mezey, Miklós Palkovits
openaire   +3 more sources

CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges

Frontiers in Pharmacology, 2021
A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves, Nickoleta Delivanoglou, Sandro Da Mesquita   +2 more
doaj   +1 more source

Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS

Frontiers in Immunology, 2023
In recent decades there has been a large focus on understanding the mechanisms of peripheral immune cell infiltration into the central nervous system (CNS) in neuroinflammatory diseases.
Collin Laaker, Cameron Baenen, Kristóf G. Kovács, Matyas Sandor, Zsuzsanna Fabry   +4 more
doaj   +1 more source

Podoplanin immunopositive lymphatic vessels at the implant interface in a rat model of osteoporotic fractures [PDF]

, 2013
Insertion of bone substitution materials accelerates healing of osteoporotic fractures. Biodegradable materials are preferred for application in osteoporotic patients to avoid a second surgery for implant replacement. Degraded implant fragments are often
Alt, Volker, Gelinsky, Michael, Hanke, Thomas, Hartmann, Sonja, Heinemann, Sascha, Heiss, Christian, Kampschulte, Marian, Kauschke, Vivien, Kautz, Armin R., Kilian, Olaf, Langheinrich, Alexander, Lips, Katrin Susanne, Ray, Seemun, Schnabelrauch, Matthias, Schnettler, Reinhard, Schumacher, Matthias, Thormann, Ulrich   +16 more
core   +6 more sources

Development and application of a novel cervical lymph collection method to assess lymphatic transport in rats

Frontiers in Pharmacology, 2023
Background: Fluids, solutes and immune cells have been demonstrated to drain from the brain and surrounding structures to the cervical lymph vessels and nodes in the neck via meningeal lymphatics, nasal lymphatics and/or lymphatic vessels associated with
Thu A. Hoang, Enyuan Cao, Gracia Gracia, Joseph A. Nicolazzo, Natalie L. Trevaskis   +4 more
doaj   +1 more source

Established, New and Emerging Concepts in Brain Vascular Development

Frontiers in Physiology, 2021
In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta, Kevin R. Rarick, Ramani Ramchandran   +2 more
doaj   +1 more source

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis [PDF]

The Journal of Immunology, 2020
Abstract Traumatic brain injury (TBI) has emerged as a leading cause of death and disability. Despite being a growing medical issue, the biological factors that promote central nervous system (CNS) pathology and neurological dysfunction following TBI remain poorly characterized.
Ashley C. Bolte, Arun B. Dutta, Mariah E. Hurt, Igor Smirnov, Michael A. Kovacs, Celia A. McKee, Hannah E. Ennerfelt, Daniel Shapiro, Bao H. Nguyen, Elizabeth L. Frost, Catherine R. Lammert, Jonathan Kipnis, John R. Lukens   +12 more
openaire   +3 more sources

Recent Advances in Glioma Cancer Treatment: Conventional and Epigenetic Realms

Vaccines, 2022
Glioblastoma (GBM) is the most typical and aggressive form of primary brain tumor in adults, with a poor prognosis. Successful glioma treatment is hampered by ineffective medication distribution across the blood-brain barrier (BBB) and the emergence of ...
Mohsen Karami Fath, Kimiya Babakhaniyan, Mehran Anjomrooz, Mohammadrasoul Jalalifar, Seyed Danial Alizadeh, Zeinab Pourghasem, Parisa Abbasi Oshagh, Ali Azargoonjahromi, Faezeh Almasi, Hafza Zahira Manzoor, Bahman Khalesi, Navid Pourzardosht, Saeed Khalili, Zahra Payandeh   +13 more
doaj   +1 more source

Functional assessment of the dural lymphatic vessels using dynamic contrast MRI in multiple sclerosis

Brain and Behavior, 2023
Background and purpose The discovery of glymphatic function in the human brain has generated interest in waste clearance mechanisms in neurological disorders such as multiple sclerosis (MS). However, noninvasive in vivo functional assessment is currently
Refaat E. Gabr, John A. Lincoln, Khader M. Hasan, Larry A. Kramer   +3 more
doaj   +1 more source

Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma

Frontiers in Oncology, 2021
Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields.
Mara De Martino, Oscar Padilla, Camille Daviaud, Cheng-Chia Wu, Cheng-Chia Wu, Robyn D. Gartrell, Claire Vanpouille-Box, Claire Vanpouille-Box   +7 more
doaj   +1 more source