Results 11 to 20 of about 12,817 (250)
Progress on Brain and Ocular Lymphatic System
BioMed Research International, 2022 In recent years, 2 major discoveries have modified the traditional understanding of the brain. First, meningeal lymphatic vessels (MLV) were found in the dural sinus, which may absorb and drain cerebrospinal fluid (CSF). Second, the glymphatic system was discovered, composed of para‐arterial CSF influx channel, paravenous interstitial fluid (ISF ...
Yang Xu +5 more
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CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
Frontiers in Pharmacology, 2021 A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves +2 more
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Frontiers in Immunology, 2023 In recent decades there has been a large focus on understanding the mechanisms of peripheral immune cell infiltration into the central nervous system (CNS) in neuroinflammatory diseases.
Collin Laaker +4 more
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An immunohistochemical study of lymphatic elements in the human brain [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance The connection between brain and peripheral lymphatics has been studied for 250 y, mainly in animals. Specific markers for lymphatic endothelial cells (LECs) were discovered about a decade ago. We stained postmortem human brains with LYVE1 and PDPN to identify LECs.
Éva Mezey +6 more
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Frontiers in Pharmacology, 2023 Background: Fluids, solutes and immune cells have been demonstrated to drain from the brain and surrounding structures to the cervical lymph vessels and nodes in the neck via meningeal lymphatics, nasal lymphatics and/or lymphatic vessels associated with
Thu A. Hoang +4 more
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Established, New and Emerging Concepts in Brain Vascular Development
Frontiers in Physiology, 2021 In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta +2 more
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Recent Advances in Glioma Cancer Treatment: Conventional and Epigenetic Realms
Vaccines, 2022 Glioblastoma (GBM) is the most typical and aggressive form of primary brain tumor in adults, with a poor prognosis. Successful glioma treatment is hampered by ineffective medication distribution across the blood-brain barrier (BBB) and the emergence of ...
Mohsen Karami Fath +13 more
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Brain and Behavior, 2023 Background and purpose The discovery of glymphatic function in the human brain has generated interest in waste clearance mechanisms in neurological disorders such as multiple sclerosis (MS). However, noninvasive in vivo functional assessment is currently
Refaat E. Gabr +3 more
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Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma
Frontiers in Oncology, 2021 Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields.
Mara De Martino +7 more
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eLife, 2017 The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish
Max van Lessen +5 more
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