Journal of Immunology Research, 2022 Alzheimer’s is characterized by accumulation of amyloid-β (Aβ) associated with insufficient clearance of toxicants from the brain establishing a chronic inflammation and other abnormalities in the brain.
Nafiseh Pakravan +2 more
doaj +1 more source
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]
, 2011 The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff +66 more
core +2 more sources
New experimental model of acute aqueductal blockage in cats: effects on cerebrospinal fluid pressure and the size of brain ventricles [PDF]
, 2009 It is generally assumed that cerebrospinal fluid (CSF) is secreted in the brain ventricles, and so after an acute blockage of the aqueduct of Sylvius an increase in the ventricular CSF pressure and dilation of isolated ventricles may be expected. We have
Božić, Borka +5 more
core +1 more source
CSF circulation and dispersion yield rapid clearance from intracranial compartments
Frontiers in Bioengineering and Biotechnology, 2022 In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles.
Martin Hornkjøl +10 more
doaj +1 more source
Antigen-presenting cells and antigen presentation in tertiary lymphoid organs [PDF]
, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Bedaj, Marija +3 more
core +1 more source
Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]
, 2017 The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka +3 more
core +1 more source
Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes
Nature Communications, 2022 Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral
Mehmet Sait Albayram +6 more
doaj +1 more source
New Brain Lymphatic Vessels Drain Old Concepts
EBioMedicine, 2015 The brain has traditionally been considered an immune privileged organ, in part due to the lack of evidence for lymphatic vasculature (Galea et al., 2007). Two centuries ago, the existence of lymphatic vessels on the surface of the human brain was proposed but it has since been widely dismissed (Lukic et al., 2003).
Dissing-Olesen, Lasse +2 more
openaire +4 more sources
Lymphatic vessels of the dura mater: A new discovery? [PDF]
, 2015 Two recent paper s (Aspelund et al. 2015; Louveau et al. 2015) reported the presence in mice of lymphatics in the cerebra l dura mater , the most external of the meningeal layers covering the brain.
Bucchieri, F. +3 more
core +1 more source
Circadian control of brain glymphatic and lymphatic fluid flow [PDF]
Nature Communications, 2020 Abstract The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular endfeet of astrocytes.
Lauren M. Hablitz +8 more
openaire +5 more sources