Results 61 to 70 of about 1,655,573 (298)

Modelling the fluid drainage through primary lymphatic valves

, 2013
This study investigates the fluid flow through tissues where lymphatic drainage occurs. Lymphatic drainage relies on two unidirectional valve systems, primary and secondary.
Heppell, Charles
core   +1 more source

Tissue Clearing and Expansion Methods for Imaging Brain Pathology in Neurodegeneration: From Circuits to Synapses and Beyond

Frontiers in Neuroscience, 2020
Studying the structural alterations occurring during diseases of the nervous system requires imaging heterogeneous cell populations at the circuit, cellular and subcellular levels.
Arnaldo Parra-Damas, Arnaldo Parra-Damas, Carlos A. Saura, Carlos A. Saura   +3 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species

Cerebrospinal Fluid Research, 2004
Background The parenchyma of the brain does not contain lymphatics. Consequently, it has been assumed that arachnoid projections into the cranial venous system are responsible for cerebrospinal fluid (CSF) absorption.
Armstrong Dianna, Salmasi Giselle, Papaiconomou Christina, Zakharov Andrei, Johnston Miles   +4 more
doaj   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Brain differences between persistent and remitted attention deficit hyperactivity disorder [PDF]

, 2014
Previous resting state studies examining the brain basis of attention deficit hyperactivity disorder have not distinguished between patients who persist versus those who remit from the diagnosis as adults.
Kagan, Elana, Spencer, Thomas, Biederman, Joseph, Brown, Ariel, Kotte, Amelia, Gabrieli, Susan, Mattfeld, Aaron T., Gabrieli, John D. E.   +7 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Dopaminergic abnormalities following traumatic brain injury [PDF]

, 2017
Traumatic brain injury can reduce striatal dopamine levels. The cause of this is uncertain, but is likely to be related to damage to the nigrostriatal system.
Svensson, W, Khan, S, Patel, M, Scott, G, Sharp, DJ, Cole, J, Bourke, N, Jenkins, PO, De Simoni, S, Fleminger, J, Towey, D, Greenwood, R   +11 more
core   +1 more source

Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance

Frontiers in Cellular Neuroscience, 2021
According to classical dogma, the central nervous system (CNS) is defined as an immune privileged space. The basis of this theory was rooted in an incomplete understanding of the CNS microenvironment, however, recent advances such as the identification ...
Dana Mitchell, Jack Shireman, Elizabeth A. Sierra Potchanant, Montserrat Lara-Velazquez, Mahua Dey   +4 more
doaj   +1 more source

Glymphatics and meningeal lymphatics unlock the brain-immune code. [PDF]

Immunity
The central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind the blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology.
Kim MW, Kipnis J.
europepmc   +5 more sources