Results 71 to 80 of about 12,817 (250)

A Simulation Model of Periarterial Clearance of Amyloid-beta from the Brain

Frontiers in Aging Neuroscience, 2016
The accumulation of soluble and insoluble amyloid-beta (A-beta) in the brain indicates failure of elimination of A-beta from the brain with age and Alzheimer's disease. There is a variety of mechanisms for elimination of A-beta from the brain.
Alexandra Katharina Diem, Alexandra Katharina Diem, Mingyi eTan, Neil W. Bressloff, Cheryl eHawkes, Alan W. J. Morris, Alan W. J. Morris, Roy O. Weller, Roxana O. Carare, Roxana O. Carare   +9 more
doaj   +1 more source

BODIPY‐based J‐aggregates: From supramolecular chemistry to NIR bioimaging and phototherapies

Bulletin of the Korean Chemical Society, EarlyView.
BODIPY dyes form ordered J‐aggregates through controlled supramolecular self‐assembly, producing narrow, red‐shifted absorption bands with small Stokes shifts. This review highlights design strategies governing J‐aggregation, structure–property relationships, and applications in sensing, bioimaging, and phototherapy, guiding functional BODIPY‐based ...
Pooja Sharma, Yeonkyeong Lee, Youngmi Kim   +2 more
wiley   +1 more source

Atypical presentation of hepatocellular carcinoma: a mass on the left thoracic wall

BMC Cancer, 2004
Background Hepatocellular carcinoma is a common malignancy for which chronic hepatitis B infection has been defined as the most common etiologic factor.
Baykara Meltem, Ceyhan Koray, Köklü Seyfettin, Yüksel Osman, Çoban Şahin, Dökmeci Abdulkadir   +5 more
doaj   +1 more source

Symposium Highlight: BRAIN LYMPHATICS: REDISCOVERY AND NEW INSIGHTS INTO LYMPHATIC INVOLVEMENT IN DISEASES OF HUMAN BRAINS

Lymphology
The brain’s lymphatic system is comprised of a glymphatic—meningeal—cervical lymphatic vessel pathway. The study of its mechanism and pathophysiology in neurodegenerative disease has been one of the most exciting topics in basic and translational neuroscience of the last decade.
M.J. Bartlett, R.P. Erickson, E.B. Hutchinson, R.S. Witte, M.H. Witte   +4 more
openaire   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Extracranial Metastases of a Cerebral Glioblastoma: A Case Report and Review of the Literature

Case Reports in Oncology, 2018
The glioblastoma, a malignant human brain tumor, is known for its devastating intracranial progress and its dismal prognosis. Whereas treatment and research are most prominently focused on the primary tumor lesion, in recent years evidence has ...
Jurij Rosen, Tobias Blau, Stefan J. Grau, Michael T. Barbe, Gereon R. Fink, Norbert Galldiks   +5 more
doaj   +1 more source

Role of meningeal lymphatic vessels in brain homeostasis

Frontiers in Immunology
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Meng-Ying Zhao, Chao-Yuan Ye, Yuan-Cheng Liu, Xiao-Ming Wang, Jun-Cai Fu, Xin-Yuan Liu, Rui Zhu, Yi-Zhao Li, Qing Tian   +8 more
openaire   +3 more sources

The anatomy and metabolome of the lymphatic system in the brain in health and disease

Brain Pathology, 2019
AbstractRecent studies have demonstrated that the brain is equipped with a lymphatic drainage system that is actively involved in parenchymal waste clearance, brain homeostasis and immune regulation. However, the exact anatomic drainage routes of brain lymph fluid (BLF) remain elusive, hampering the physiological study and clinical application of this ...
Wenbo He, You Jing, Qianfen Wan, Ke Xiao, Kening Chen, Yuan Lu, Liang Li, Yajie Tang, Yunte Deng, Zhaohui Yao, Junqiu Yue, Gang Cao   +11 more
openaire   +3 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Extraneural Metastasis of Primary Glioma Occurring in a Setting of Occupational Ionizing Radiation Exposure

Case Reports in Neurological Medicine, 2019
Malignant gliomas account for 60% of all primary brain tumors in adults. Glioblastoma Multiforme (GBM) is the most common primary glial tumor with a dismal prognosis and a median survival of approximately 14 months.
Nitya Prabhakaran, Douglas C. Miller, N. Scott Litofsky, Shellaine R. Frazier   +3 more
doaj   +1 more source