Results 71 to 80 of about 1,655,573 (298)
Lymphatics and the Brain [PDF]
Circulation Research, 2021 Benjamin M. Hogan, Neil I. Bower
openaire +4 more sources
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao +19 more
wiley +1 more source
Brain Lymphatics Measurements from MRI - Guidelines
The process detailed in this document is associated with a published investigation into semi-quantitatively measuring and visualising brain fluid pathways, including meningeal lymphatics, using magnetic resonance imaging (MRI) - Sennfalt et al., (2023 ...
Wardlaw, Joanna M +3 more
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Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
, 2009 Inflammation is a local or systemic tissue reaction caused by external or internal stimuli with the objective to remove the noxa, inhibit its further dissemination and eventually repair damaged tissue. Blood vessels and perivascular connective tissue are
Wilting, J. +3 more
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A Study of Brain Networks Associated with Swallowing Using Graph-Theoretical Approaches [PDF]
, 2013 Functional connectivity between brain regions during swallowing tasks is still not well understood. Understanding these complex interactions is of great interest from both a scientific and a clinical perspective.
Bo Luan +12 more
core +2 more sources
Draining the Brain: A Novel Noninvasive Lymphatic Therapy for Parkinson’s Disease
LymphaticsThe discovery of the glymphatic system and meningeal lymphatic vessels established that the brain possesses an organized lymphatic clearance network that drains to the deep cervical lymphatics.
Yazan Mahafza +4 more
doaj +1 more source
Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy
Advanced Science, EarlyView.Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao +2 more
wiley +1 more source
Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy
Advanced Science, EarlyView.A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao +10 more
wiley +1 more source