Results 91 to 100 of about 1,655,573 (298)

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

Antigen-specific immune reactions to ischemic stroke

Frontiers in Cellular Neuroscience, 2014
Brain proteins are detected in the CSF and blood of stroke patients and their concentration is related to the extent of brain damage. Antibodies against brain antigens develop after stroke, suggesting a humoral immune response to the brain injury ...
Xabier eUrra, Xabier eUrra, Francesc eMiró, Ángel eChamorro, Ángel eChamorro, Anna M Planas, Anna M Planas   +6 more
doaj   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Lung lymphatics cast from the airspace

, 1994
Lymphatics are important in the resolution of pulmonary edema, but which lymphatics drain alveolar fluid and how they change during lung injury and edema is uncertain. To study this question 16 rats were exposed to 85% O2 for 7 days.
K. D. Hainis, J. I. Sznajder, D. E. Schraufnagel   +2 more
core   +1 more source

A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li, Yujie Chen, Rongsu Huang, Min Xia, Chao Mi, Yuan Tian, Peiwen Guo, Taotao Jin, Shilei Hao, Hua Feng, Yujie Chen, Zhi Chen   +11 more
wiley   +1 more source

Brain tissue properties differentiate between motor and limbic basal ganglia circuits [PDF]

, 2014
Despite advances in understanding basic organizational principles of the human basal ganglia, accurate in vivo assessment of their anatomical properties is essential to improve early diagnosis in disorders with corticosubcortical pathology and optimize ...
Haynes, J., Weiskopf, N, Ettore A. Accolla, Dukart, J., Kherif, Ferath, Weiskopf, N. ; https://orcid.org/, Kuehn, Andrea A., Helms, Gunther, Gunther Helms, Weiskopf, Nikolaus, Rumana Chowdhury, John‐Dylan Haynes, Chowdhury, R., Dukart, Jürgen, Draganski, Bogdan, Stefan Hetzer, Hetzer, S, Kühn, Andrea A., Draganski, B. ; https://orcid.org/, Accolla, E., Haynes, John-Dylan, Ferath Kherif, Juergen Dukart, Kühn, AA, Accolla, Ettore A., Chowdhury, R, Andrea A. Kühn, Dukart, Juergen, Chowdhury, Rumana, Hetzer, Stefan, Antoine Lutti, Hetzer, S., Lutti, Antoine, Accolla, EA, Draganski, B, Helms, Gunther,, Nikolaus Weiskopf, Kühn, A., Bogdan Draganski, Kherif, F., Kherif, F, Helms, G., Helms, G, Lutti, A, Lutti, A., Lund University., Dukart, J, Haynes, J-D   +47 more
core   +1 more source

Phototherapy of Alzheimer's Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review. [PDF]

Int J Mol Sci, 2023
Semyachkina-Glushkovskaya O, Penzel T, Poluektov M, Fedosov I, Tzoy M, Terskov A, Blokhina I, Sidorov V, Kurths J.   +8 more
europepmc   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, EarlyView.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Meningeal lymphatics can influence stroke outcome [PDF]

Meningeal lymphatics are conduits for cerebrospinal fluid drainage to lymphatics and lymph nodes in the neck. In this issue of JEM, Boisserand et al. (https://doi.org/10.1084/jem.20221983) provide evidence that expansion of meningeal lymphatics protects ...
Koh, Gou Young, McDonald, Donald M
core   +1 more source

A Simulation Model of Periarterial Clearance of Amyloid-beta from the Brain

Frontiers in Aging Neuroscience, 2016
The accumulation of soluble and insoluble amyloid-beta (A-beta) in the brain indicates failure of elimination of A-beta from the brain with age and Alzheimer's disease. There is a variety of mechanisms for elimination of A-beta from the brain.
Alexandra Katharina Diem, Alexandra Katharina Diem, Mingyi eTan, Neil W. Bressloff, Cheryl eHawkes, Alan W. J. Morris, Alan W. J. Morris, Roy O. Weller, Roxana O. Carare, Roxana O. Carare   +9 more
doaj   +1 more source