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mGem: Applying microbiome therapeutic learnings to next-generation agricultural bioproducts [PDF]
mBioBiological discoveries in plant and human systems have long advanced our understanding of how signaling, metabolism, and immunity shape cross-kingdom interactions.
Eric C. Holmes
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Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models [PDF]
Frontiers in Immunology, 2020 Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes.
Dorothy K. Sojka
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Human–Machine Scientific Discovery [PDF]
, 2021 Humanity is facing existential, societal challenges related to food security, ecosystem conservation, antimicrobial resistance, etc, and Artificial Intelligence (AI) is already playing an important role in tackling these new challenges. Most current AI approaches are limited when it comes to ‘knowledge transfer’ with humans, i.e.
Tamaddoni-Nezhad, Alireza +4 more
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Discovery proteomics of human placental tissue [PDF]
Rapid Communications in Mass Spectrometry, 2021 We describe a label‐free proteomics protocol for the interrogation of the placental proteome. Step‐by‐step directions, including tissue cleanup and preparation, proteolytic digestion, nanoLC–MS/MS data collection and data analysis, are provided. The workflow has been applied toward exploring differential protein expression patterns in placentas from ...
Allyson L. Mellinger +3 more
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Human Embryo Models and Drug Discovery [PDF]
International Journal of Molecular Sciences, 2021 For obvious reasons, such as, e.g., ethical concerns or sample accessibility, model systems are of highest importance to study the underlying molecular mechanisms of human maladies with the aim to develop innovative and effective therapeutic strategies.
Margit Rosner +3 more
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Sensors, 2023 The emergence of the global coronavirus pandemic in 2019 (COVID-19 disease) created a need for remote methods to detect and continuously monitor patients with infectious respiratory diseases.
Jinho Park +6 more
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Disease Models & Mechanisms, 2020 Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder caused by mutations in peroxisomal genes essential for plasmalogen biosynthesis.
Wedad Fallatah +6 more
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Human viruses: discovery and emergence [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2012 There are 219 virus species that are known to be able to infect humans. The first of these to be discovered was yellow fever virus in 1901, and three to four new species are still being found every year. Extrapolation of the discovery curve suggests that there is still a substantial pool of undiscovered human virus species, although an apparent slow ...
Woolhouse, Mark +4 more
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Human coronaviruses and therapeutic drug discovery [PDF]
Infectious Diseases of Poverty, 2021 Abstract Background Coronaviruses (CoVs) are distributed worldwide and have various susceptible hosts; CoVs infecting humans are called human coronaviruses (HCoVs). Although HCoV-specific drugs are still lacking, many potent targets for drug discovery are being explored, and many vigorously designed clinical trials are ...
Lan-Gui Song +3 more
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Frontiers in Neurology, 2023 IntroductionTraumatic spinal cord injury (tSCI) is a debilitating neurological condition resulting in lifelong disability for many individuals. The primary objectives of our study were to describe national trends in incident emergency department (ED ...
James A. G. Crispo +17 more
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