Results 11 to 20 of about 143,716 (257)

Human babesiosis: Recent discoveries

Medicinski pregled, 2004
Introduction Babesiosis is caused by intraerythrocytic parasites of the genus Babesia, which is a common animal infection worldwide. This protozoa requires both a competent vertebrate and a nonvertebrate host (Ixodes sp. etc.) to maintain the transmission cycle.
Sanja, Mitrović, Ivana, Kranjcić-Zec, Valentina, Arsić-Arsenijević, Aleksandar, Dzamić, Ivana, Radonjić   +4 more
openaire   +3 more sources

Human Embryo Models and Drug Discovery [PDF]

International Journal of Molecular Sciences, 2021
For obvious reasons, such as, e.g., ethical concerns or sample accessibility, model systems are of highest importance to study the underlying molecular mechanisms of human maladies with the aim to develop innovative and effective therapeutic strategies.
Margit Rosner, Manuel Reithofer, Dieter Fink, Markus Hengstschläger   +3 more
openaire   +2 more sources

Spinal Cord Excitability and Sprint Performance Are Enhanced by Sensory Stimulation During Cycling

Frontiers in Human Neuroscience, 2017
Spinal cord excitability, as assessed by modulation of Hoffmann (H-) reflexes, is reduced with fatiguing isometric contractions. Furthermore, spinal cord excitability is reduced during non-fatiguing arm and leg cycling.
Gregory E. P. Pearcey, Gregory E. P. Pearcey, Gregory E. P. Pearcey, Steven A. Noble, Steven A. Noble, Steven A. Noble, Bridget Munro, E. Paul Zehr, E. Paul Zehr, E. Paul Zehr, E. Paul Zehr   +10 more
doaj   +1 more source

After stroke bidirectional modulation of soleus stretch reflex amplitude emerges during rhythmic arm cycling

Frontiers in Human Neuroscience, 2014
Objectives: After stroke a typical presentation is exaggerated stretch reflexes (SR) on the more affected (MA) side. The present study evaluated the contribution of presynaptic inhibition (PSI) induced by arm cycling and homosynaptic depression (HD) to ...
Rinaldo André Mezzarane, Rinaldo André Mezzarane, Tsuyoshi eNakajima, Tsuyoshi eNakajima, E Paul eZehr, E Paul eZehr, E Paul eZehr, E Paul eZehr   +7 more
doaj   +1 more source

Human Genomics Brief Reports: embracing concise dissemination for rapid and impactful discoveries

Human Genomics
Vasilis Vasiliou, Juergen K.V. Reichardt, Bassam R. Ali   +2 more
doaj   +2 more sources

Retinoic Acid and Retinoid X Receptors

Cells, 2023
One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
doaj   +1 more source

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Frontiers in Pharmacology, 2023
The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device ...
Naina Sunildutt, Pratibha Parihar, Abdul Rahim Chethikkattuveli Salih, Sang Ho Lee, Kyung Hyun Choi   +4 more
doaj   +1 more source

Cross-pollination of research findings, although uncommon, may accelerate discovery of human disease genes

BMC Medical Genetics, 2012
Background Technological leaps in genome sequencing have resulted in a surge in discovery of human disease genes. These discoveries have led to increased clarity on the molecular pathology of disease and have also demonstrated considerable overlap in the
Duda Marlena, Nelson Tristan, Wall Dennis P   +2 more
doaj   +1 more source

How many human pathogens are there in Laos? An estimate of national human pathogen diversity and analysis of historical trends

BMJ Global Health, 2020
Objective The emergence of infectious diseases pose major global health threats. Estimates of total in-country human pathogen diversity, and insights as to how and when species were described through history, could be used to estimate the probability of ...
Paul N Newton, Madeleine Claire Clarkson, Ricardo Aguas, Kathryn Sweet, Tamalee Roberts, Michel Strobel   +5 more
doaj   +1 more source

Chronobiology: Discovery of the molecular mechanisms of circadian rhythm

Journal of Mental Health and Human Behaviour, 2018
Advances in the field chronobiology have potential implications for physical as well as mental health and human behavior. Several paradigm-shifting discoveries established key mechanistic principles for the biological clock.
Pooja Shakya, Shyama Nand Roy, Raman Deep   +2 more
doaj   +1 more source