Results 21 to 30 of about 143,716 (257)

On the growth of scientific knowledge: yeast biology as a case study. [PDF]

open access: yesPLoS Computational Biology, 2009
The tempo and mode of human knowledge expansion is an enduring yet poorly understood topic. Through a temporal network analysis of three decades of discoveries of protein interactions and genetic interactions in baker's yeast, we show that the growth of ...
Xionglei He, Jianzhi Zhang
doaj   +1 more source

New discoveries on the biology and detection of human chorionic gonadotropin

open access: yesReproductive Biology and Endocrinology, 2009
Human chorionic gonadotropin (hCG) is a glycoprotein hormone comprising 2 subunits, alpha and beta joined non covalently. While similar in structure to luteinizing hormone (LH), hCG exists in multiple hormonal and non-endocrine agents, rather than as a ...
Cole Laurence A
doaj   +1 more source

Human Activity Recognition and Pattern Discovery [PDF]

open access: yesIEEE Pervasive Computing, 2010
In principle, activity recognition can be exploited to great societal benefits, especially in real-life, human centric applications such as elder care and healthcare. This article focused on recognizing simple human activities. Recognizing complex activities remains a challenging and active area of research and the nature of human activities poses ...
Eunju Kim, Sumi Helal, Diane J. Cook
openaire   +3 more sources

A GLOBAL MODEL OF ECONOMIC EFFICIENCY [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
Idea generators are the intellectual producers of scientific discoveries, but training them up is becoming increasingly more expensive every year. The training process is sustained by technology, and the conditions in which they operate. Over the last
STEGĂROIU CARINA-ELENA
doaj  

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier   +10 more
wiley   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar   +7 more
wiley   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall   +2 more
wiley   +1 more source

Phosphoproteome Discovery in Human Biological Fluids [PDF]

open access: yesProteomes, 2016
Phosphorylation plays a critical role in regulating protein function and thus influences a vast spectrum of cellular processes. With the advent of modern bioanalytical technologies, examination of protein phosphorylation on a global scale has become one of the major research areas. Phosphoproteins are found in biological fluids and interrogation of the
Francesco Giorgianni   +1 more
openaire   +3 more sources

HuCurl: Human-induced Curriculum Discovery

open access: yesProceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2023
We introduce the problem of curriculum discovery and describe a curriculum learning framework capable of discovering effective curricula in a curriculum space based on prior knowledge about sample difficulty. Using annotation entropy and loss as measures of difficulty, we show that (i): the top-performing discovered curricula for a given model and ...
Mohamed Elgaar, Hadi Amiri
openaire   +2 more sources

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge   +6 more
wiley   +1 more source

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