Results 41 to 50 of about 155,859 (254)
Using the Concept of Serendipity in Education [PDF]
, 2007 The word "serendipity" was introduced to the field of science by Merton while studying the progress of science and noticed that accidental discoveries often contributed to its progress.
Sawaizumi, Shigekazu +3 more
core
Human Origins and the Search for “Missing Links”.
PLoS Biology, 2012 The study of human evolution is filled with exciting discoveries, contentious disputes, and immense promise. Johannes Krause reviews John Reader's book on the history of paleoanthropology.
Johannes Krause
doaj +1 more source
TREM2 dependent and independent functions of microglia in Alzheimer’s disease
Molecular Neurodegeneration, 2022 Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of ...
Jinchao Hou +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Applied SciencesNon-contact anterior cruciate ligament (ACL) injuries cause substantial time loss in female football. Although altered lower-limb muscle excitation is a modifiable risk factor, the reliability of surface electromyography (sEMG) during dynamic tasks in ...
Andrew Frampton +4 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A freshwater diet-derived 14C reservoir effect at the Stone Age sites in the Iron Gates gorge [PDF]
, 2001 Human bones from single inhumation burials and artifacts made from terrestrial mammal (ungulate) bone found in direct association with the skeletons were obtained from the Stone Age site of Schela Cladovei situated just below the Iron Gates Gorge of the ...
McSweeney, Kathleen +11 more
core +1 more source
Journal of CheminformaticsCurrent strategies centred on either merging or linking initial hits from fragment-based drug design (FBDD) crystallographic screens generally do not fully leaverage 3D structural information.
Matteo P. Ferla +7 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source