Results 51 to 60 of about 148,186 (216)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?
Frontiers in Microbiology, 2017 Bacterial and viral co-infections of the respiratory tract are life-threatening and present a global burden to the global community. Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes are frequent colonizers of the upper ...
Nikolai Siemens +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
New discoveries and re-discoveries of human remains from the late Middle Pleistocene (
Bulletins et Mémoires de la Société d’Anthropologie de Paris, 2023 Amélie Vialet +10 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Wilderness Immersion Tuning: Education with Evolution and Neuroscience in Mind
Encounters in Theory and History of Education, 2016 These combined two papers make the case that certain kinds of learning in relatively less human-directed environments, which we call wilderness immersion tuning, not only make good evolutionary and neuroscience sense, but are needed for the optimal ...
Chris Beeman, Eric B. Walton
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The fifth era of science: Artificial scientific intelligence.
PLoS BiologyThe era of artificial scientific intelligence is here. As algorithms generate discoveries at scale, what role remains for human scientists?
Nina Miolane
doaj +1 more source
New discoveries of Middle Paleolithic human remains from the “Bau de l'Aubésier (Vaucluse, France)”
Bulletins et Mémoires de la Société d’Anthropologie de Paris, 2001 Excavations in Middle Paleolithic levels at the “Bau de l’Aubésier (Vaucluse)” during 2000 yielded a maxillary molar and a partial mandible from late Middle Pleistocene levels, plus a maxillary molar from the early Late Pleistocene.
Serge Lebel, Erik Trinkaus
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source