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The completion of the Human Genome Project in 2003 continues to raise expectations on near-term applications of human genome discoveries in personalized disease prevention, especially in the area of common chronic diseases (1,2). In fact, almost daily we
George A. Mensah, MD +1 more
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Comparative Aspects of Osteosarcoma Pathogenesis in Humans and Dogs
Osteosarcoma (OS) is a primary and aggressive bone sarcoma affecting the skeleton of two principal species, human beings and canines. The biologic behavior of OS is conserved between people and dogs, and evidence suggests that fundamental discoveries in ...
Timothy M. Fan, Chand Khanna
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Abstract The application of genome-wide technologies has accelerated the discovery of genetic and genomic etiologies for the epilepsies. Gene discovery has been most successful in the developmental and epileptic encephalopathies, and genetic testing is now routinely implemented in the clinical setting.
Emily S. Bonkowski, Heather C. Mefford
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Human Discovery and Machine Learning
This article studies machine learning paradigms from the point of view of human cognition. Indeed, conceptions in both machine learning and human learning evolved from a passive to an active conception of learning. Our objective is to provide an interaction protocol suited to both humans and machines to enable assisting human discoveries by learning ...
Dartnell, Christopher +3 more
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Virtual Astronomy, Information Technology, and the New Scientific Methodology [PDF]
All sciences, including astronomy, are now entering the era of information abundance. The exponentially increasing volume and complexity of modern data sets promises to transform the scientific practice, but also poses a number of common technological ...
Djorgovski, S. G.
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Technology Transfer and the Genome Project: Problems with Patenting Research Tools [PDF]
Professor Eisenberg argues against a system providing for federally-sponsored inventions to be patented if any associated person so desires. She believes that the system does not adequately weigh the possibility that the greatest social return from ...
Eisenberg, Rebecca S.
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The Human Genome Project and the Downside of Federal Technology Transfer [PDF]
Mr. Harnett argues that emphasizing technology transfer at institutions such as the National Institutes of Health will interfere with what should be regarded as their primary mission, basic ...
Harnett, Christopher J.
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Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?
Bacterial and viral co-infections of the respiratory tract are life-threatening and present a global burden to the global community. Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes are frequent colonizers of the upper ...
Nikolai Siemens +6 more
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Fundamental changes are taking place in the way we do astronomy. In twenty years time, it is likely that most astronomers will never go near a cutting-edge telescope, which will be much more efficiently operated in service mode.
Norris, Ray P.
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Genome editing in non-model organisms opens new horizons for comparative physiology [PDF]
For almost 100 years, biologists have made fundamental discoveries using a handful of model organisms that are not representative of the rich diversity found in nature.
Dickinson, Michael H. +2 more
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