Results 81 to 90 of about 143,716 (257)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A historical reflection on the discovery of human retroviruses [PDF]
Retrovirology, 2009 The discovery of HIV-1 as the cause of AIDS was one of the major scientific achievements during the last century. Here the events leading to this discovery are reviewed with particular attention to priority and actual contributions by those involved.
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Perspectives on the physics of late-type stars from beyond low earth orbit, the moon and mars
npj MicrogravityWith the new discoveries enabled thanks to the recent space missions, stellar physics is going through a revolution. However, these discoveries opened the door to many new questions that require more observations.
Savita Mathur, Ângela R. G. Santos
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Big Data is a big lie without little data: Humanistic intelligence as a human right
Big Data & Society, 2017 This article introduces an important concept: Transparency by way of Humanistic Intelligence as a human right, and in particular, Big/Little Data and Sur/Sous Veillance, where “Little Data” is to sousveillance (undersight) as “Big Data” is to ...
Steve Mann
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
История изучения и открытия археологических памятников города Волжска (Республика Марий Эл)
Forum WschodnieThe article describes the history of discoveries and studies of archaeological sites in the city of Volzhsk (Republic of Mari El) during the Mesolithic and Neolithic periods.
Pavel Georgiyev, Yelena Shornikova
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Cucurbitacin: Ancient Compound Shedding New Light on Cancer Treatment
The Scientific World Journal, 2010 Cucurbitacins and their derivatives are triterpenoids found in medicinal plants known for their diverse pharmacological and biological activities, including anticancer effects, throughout human history.
Dhong Hyun Lee +2 more
doaj +1 more source