Results 71 to 80 of about 143,716 (257)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The fifth era of science: Artificial scientific intelligence.
PLoS BiologyThe era of artificial scientific intelligence is here. As algorithms generate discoveries at scale, what role remains for human scientists?
Nina Miolane
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Wilderness Immersion Tuning: Education with Evolution and Neuroscience in Mind
Encounters in Theory and History of Education, 2016 These combined two papers make the case that certain kinds of learning in relatively less human-directed environments, which we call wilderness immersion tuning, not only make good evolutionary and neuroscience sense, but are needed for the optimal ...
Chris Beeman, Eric B. Walton
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
New discoveries of Middle Paleolithic human remains from the “Bau de l'Aubésier (Vaucluse, France)”
Bulletins et Mémoires de la Société d’Anthropologie de Paris, 2001 Excavations in Middle Paleolithic levels at the “Bau de l’Aubésier (Vaucluse)” during 2000 yielded a maxillary molar and a partial mandible from late Middle Pleistocene levels, plus a maxillary molar from the early Late Pleistocene.
Serge Lebel, Erik Trinkaus
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation
Journal of Cardiovascular Development and DiseaseThe limited capacity for cardiomyocyte proliferation in the adult human heart restricts its ability to recover from injury. Building on discoveries in regenerative model systems, such as zebrafish and neonatal mice, reactivation of a latent potential for
Richard D. McLane +3 more
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Short Note: Human Footprints found in Central Mexico could be at least 40,000 years old [PDF]
Geofísica Internacional, 2007 Recent studies from genetics of human populations and discoveries of new occupation sites have challenged the conventional model and earlier time framework of the earliest human migration into the American continent.
A. M. Soler-Arechalde +3 more
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