Results 91 to 100 of about 155,859 (254)

Teachers entrepreneurial pedagogical content knowledge roles in human resource development [PDF]

, 2015
Among one of the strategic plan that's being enforced by Malaysia in generating a creative and innovative human resource is by strengthening the entrepreneurship education.
Abdul Manaf, Umi Kalthom, Lope Pihie, Zaidatol Akmaliah, Abdul Rahman, Fadzilah, Sipon, Merhayati   +3 more
core   +1 more source

Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation

Journal of Cardiovascular Development and Disease
The limited capacity for cardiomyocyte proliferation in the adult human heart restricts its ability to recover from injury. Building on discoveries in regenerative model systems, such as zebrafish and neonatal mice, reactivation of a latent potential for
Richard D. McLane, Abhay Cheruku, Ashley B. Williams, Ravi Karra   +3 more
doaj   +1 more source

Short Note: Human Footprints found in Central Mexico could be at least 40,000 years old [PDF]

Geofísica Internacional, 2007
Recent studies from genetics of human populations and discoveries of new occupation sites have challenged the conventional model and earlier time framework of the earliest human migration into the American continent.
A. M. Soler-Arechalde, J. Urrutia-Fucugauchi, A. Gogichaishvili, A. L. Martin-del-Pozo   +3 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Perspectives on the physics of late-type stars from beyond low earth orbit, the moon and mars

npj Microgravity
With the new discoveries enabled thanks to the recent space missions, stellar physics is going through a revolution. However, these discoveries opened the door to many new questions that require more observations.
Savita Mathur, Ângela R. G. Santos
doaj   +1 more source

Big Data is a big lie without little data: Humanistic intelligence as a human right

Big Data & Society, 2017
This article introduces an important concept: Transparency by way of Humanistic Intelligence as a human right, and in particular, Big/Little Data and Sur/Sous Veillance, where “Little Data” is to sousveillance (undersight) as “Big Data” is to ...
Steve Mann
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Discovery Is Never By Chance: Designing for (Un)Serendipity

, 2009
Serendipity has a long tradition in the history of science as having played a key role in many significant discoveries. Computer scientists, valuing the role of serendipity in discovery, have attempted to design systems that encourage serendipity ...
André, Paul, Teevan, Jaime, schraefel, m.c., Dumais, Susan T.   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source