Results 111 to 120 of about 155,859 (254)
BENCH TO BEDSIDE: CHALLENGES AND OPPORTUNITIES IN LOW- AND MIDDLE-INCOME COUNTRIES
Liaquat Medical Research JournalTranslational research is a modern era of medical and clinical research where basic research discoveries are brought in the clinical practice to the patient care.
Binafsha Manzoor Syed
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Purpose: The aim of the study was to investigate ethical implications of emerging technologies and scientific discoveries for human dignity and rights in Rwanda Methodology: This study adopted a desk methodology.
Kalisa, Kelly
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Cognitive Sciences and Iain Banks’s Novels: The Wasp Factory and Use of Weapons [PDF]
Polish Journal of English Studies, 2016 The aim of this paper is to discuss Iain Banks’s Use of Weapons (1990) and Wasp Factory (1984) in the context of the presentation of the workings of the human mind in both novels – paying special attention to the relationships this presentation has with ...
Katarzyna Fetlińska
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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A Linguistic Discovery Program that Verbalizes its Discoveries
, 2008 We describe a discovery program, called UNIVAUTO (UNIVersals AUthoringTOol), whose domain of application is the study of language universals, a classic trend in contemporary linguistics.
Vladimir Pericliev
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Ontogenetic perspectives on modern human long bone growth: the humerus [PDF]
, 2015 Biological anthropologists routinely infer ancient human behaviour from macroscopic skeletal markers, although the underlying relationship between bone growth and functional adaptation remains complex.
Pitfield, Rosie
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Christian anthropology: problems and discoveries.
, 2014 The question of who and what is a human being as an anthropological question today is important not only for the social future, but for the renewal of the Church as well, witnessing the unconditional worth of a person independently of his abilities ...
Laumenskaitė, Irena Eglė +1 more
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