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Discovery of the First Human Stereotactic Instrument
Stereotactic and Functional Neurosurgery, 1983It has been uncovered that the first human stereotactic instrument was designed around 1918, but was never put to human use. It was designed after the Horsley-Clarke animal apparatus by an engineer, <i>Aubrey Mussen. </i>The history surrounding that historical event is revealed in a series of letters between the engineer and his son some ...
A, Olivier, G, Bertrand, C, Picard
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Discovery of Unprecedented Human Stercobilin Conjugates
Drug Metabolism and DispositionTwo unique metabolites (M18 and M19) were detected in feces of human volunteers dosed orally with [14C]inavolisib with a molecular ion of parent plus 304 Da. They were generated in vitro by incubation with fecal homogenates and we have evidence that they are formed chemically and possibly enzymatically.
Sungjoon Cho +9 more
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The use of human tissue in drug discovery
Cell and Tissue Banking, 2010Experiments conducted on human tissue samples are a key component of modern drug discovery programs and complement the use of animal tissue based assays in this process. Such studies can (i) enhance our understanding of disease pathophysiology, (ii) increase (or decrease) confidence that modulating the function of particular molecular targets will have
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The discovery of human monogenic obesity
Nature Reviews Endocrinology, 2023openaire +2 more sources
The discovery of human placental lactogen
American Journal of Obstetrics and Gynecology, 1974Y, Ito, K, Higashi
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Gaining insight into metabolic diseases from human genetic discoveries
Trends in Genetics, 2021Katalin Suszták, Mélina Claussnitzer
exaly
Discovery: Discovery and Inspection of Buried Human Body
Michigan Law Review, 1911openaire +2 more sources