Results 101 to 110 of about 7,975,927 (282)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Human-Induced Disturbance Alters Pollinator Communities in Tropical Mountain Forests

Diversity, 2012
Mountain forest ecosystems in the Andes are threatened by deforestation. Increasing fire frequencies lead to fire-degraded habitats that are often characterized by a persistent fern-dominated vegetation.
Matthias Schleuning, Stephan G. Beck, Isabell Hensen, Stephan Kambach, Fernando Guerra   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Effects of human disturbance on cave-nesting seabirds: the case of the storm petrel [PDF]

, 2015
"Human disturbance is an important stress factor with potentially strong impact on breeding activity in animals. The consequences can be extinction of the breeding population, because disturbed animals might desert their breeding area and find no ...
Cecilia Soldatini
core   +1 more source

Habituation reverses fear‐based ecological effects in brown bears (Ursus arctos)

Ecosphere, 2016
Fear induced by human activity is increasingly becoming recognized to influence both behavior and population biology of wildlife. Exposure to human activity can cause animals to avoid human‐dominated areas or shift temporal activity patterns, but ...
Rachel E. Wheat, Christopher C. Wilmers
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The ecological footprint of recreation: Impacts on mountain goat habitat selection

Ecosphere
Understanding the relationship between wildlife and their environment is important to wildlife management. Factors such as human disturbance that influence the behavior of animals have implications for management decisions and are critical to consider in
Kaitlin Macdonald, Kelly Proffitt, Julie Cunningham, Jay Rotella   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Contrasting Daytime Habitat Selection in Wild Red Deer Within and Outside Hunting Ban Areas Emphasises Importance of Small‐Scale Refuges From Humans

Ecology and Evolution
Prey species such as red deer (Cervus elaphus) select their habitats according to their requirements for landscape features and adapt this selection to the presence of predators and humans. We tested how networks of different types of protected areas—the
Thomas Rempfler, Wibke Peters, Claudio Signer, Flurin Filli, Hannes Jenny, Klaus Hackländer, Sven Buchmann, Pia Anderwald   +7 more
doaj   +1 more source