Results 61 to 70 of about 831,336 (352)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Detecting Range Shrinking From Historical Amphibian Species Occurrences Under Influence of Human Impacts: A Case Study Using the Chinese Giant Salamander, Andrias davidianus

Ecology and Evolution
Amphibian declines, driven by climate change (e.g., shifting temperatures, altered precipitation) and human activities like deforestation, agriculture, and urbanization, may lead to local extinctions.
Siqing Li, Wenyu Dai, Zhenkang Wang, Zhaoning Wu, Jiechen Wang   +4 more
doaj   +1 more source

Human Disturbance of Karst Environments

, 2011
Karst environments have been impacted by human activity for thousands of years, ever since people started living in caves for shelter, needing building supplies and water. As human population has increased, so has its disturbance of the karst landscape.
van Beynen, Philip E., van Beynen, Kaya
openaire   +2 more sources

Management in relation to disturbance in the boreal forest [PDF]

, 1999
http://www.elsevier.com/locate/issn/03781127Disturbances and the consequent habitat heterogeneity are natural features of the boreal forest. Natural disturbances occurring at the level of populations, communities and ecosystems (meters to kilometers and ...
Niemelä, J.
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Human Impacts on Forest Biodiversity in Protected Walnut-Fruit Forests in Kyrgyzstan [PDF]

, 2014
We used a spatially explicit model of forest dynamics, supported by empirical field data and socioeconomic data, to examine the impacts of human disturbances on a protected forest landscape in Kyrgyzstan.
Abdymomunov R. A., Adrian C. Newton, Alexander Lovegrove, Almaz Orozumbekov, Arnold J., Bengtsson J., Blaser J., CABI, Carey C., Chemonics International Inc, Chyngojoev A., Core E. L., Cremer K., Dzhangaliev A. D., Dzhangaliev A. D., Eastwood A., Elena Cantarello, Ellenberg H., Food and Agriculture Organization of the United Nations, Greene D. F., Hemery G. E., Herold B., Jahn G., Jennifer Birch, Juniper B. E., Kolov O., Kyrgyz Forest Service, Kyrgyz Forest Service, Lockwood M., Mattock J., Musuraliev T. M., Müller-Schneider P., Müller-Schneider P., Newton A. C., Newton A. C., Niels Brouwers, Orozumbekov A., Orozumbekov A., Paganová V., Peter D., Phillips A., Schmidt K., Secretariat of the Convention on Biological Diversity, Sherbinina E. N., Spencer W. D., Sukacev V. N., Venglovsky B. I., Wyckoff G. W.   +47 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The forester\u27s dilemma : paradoxes in the criteria and indicators for sustainable forestry [PDF]

, 2001
Since sustainable forestry is a complex endeavor, paradoxes naturally exist in the certification criteria and indicators. There are different ways to establish the sustainability horizon and alternative harvest profiles that, although sustainable, may ...
Howard, Theodore E.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source