N‐Truncated Superoxide Dismutase‐1 in Cerebrospinal Fluid Is Folded and Active
Superoxide dismutase 1 (SOD1) mutations cause amyotrophic lateral sclerosis (ALS) through mechanisms involving protein misfolding and aggregation. While C‐terminal truncations of SOD1 promote neurotoxicity, our study reveals that approximately one‐third of SOD1 in cerebrospinal fluid (CSF) is N‐terminally truncated—a striking observation given the ...
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