Results 71 to 80 of about 3,268,799 (291)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

“Voices from the Deck”: Evacuation Effectiveness on Cruise and Passenger Ships through Seafarers’ Perspectives and Literature Analysis [PDF]

TransNav
The effectiveness of cruise/passenger ship evacuation is influenced by multiple factors. This paper investigates the limitations of current evacuation protocols by examining crew training practices, human behavioral and psychological patterns during ...
Antonios Andreadakis, Dimitrios Dalaklis
doaj   +1 more source

CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]

, 2019
The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad, DiRusso, Christopher J., Gilmore, Thomas D., Kagermazova, Larisa, Liu, Yuekun, McCaslin, Ethan Z., Miyamoto, Shigeki, Wuerzberger-Davis, Shelly M., Yeo, Alan T.   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Review of the Global Seafarers Market [PDF]

TransNav
About 90% of world trade is carried by ships and this trade would not be possible without well-trained and experienced seafarers. There are currently over 100,000 merchant ships manned by almost 2 million seafarers.
Zvonimir LuŁic, Stipe Galic
doaj   +1 more source

Tracing the mobility of a Late Epigravettian (~ 13 ka) male infant from Grotte di Pradis (Northeastern Italian Prealps) at high-temporal resolution

Scientific Reports, 2022
We present the results of a multi-disciplinary investigation on a deciduous human tooth (Pradis 1), recently recovered from the Epigravettian layers of the Grotte di Pradis archaeological site (Northeastern Italian Prealps).
Federico Lugli, Alessia Nava, Rita Sorrentino, Antonino Vazzana, Eugenio Bortolini, Gregorio Oxilia, Sara Silvestrini, Nicola Nannini, Luca Bondioli, Helen Fewlass, Sahra Talamo, Edouard Bard, Lucia Mancini, Wolfgang Müller, Matteo Romandini, Stefano Benazzi   +15 more
doaj   +1 more source

Effects of selenium biofortification on crop nutritional quality [PDF]

, 2015
Selenium (Se) at very low doses has crucial functions in humans and animals. Since plants represent the main dietary source of this element, Se-containing crops may be used as a means to deliver Se to consumers (biofortification). Several strategies have
Dall'Acqua, Stefano, Elizabeth A. H., Pilon Smits, Malagoli, Mario, Schiavon, Michela   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

THE CALCULATION OF THE EFFICIENCY OF THE PERSONNEL ELEMENT OF THE POTENTIAL INTANGIBLE ASSETS OF INDUSTRIAL ENTERPRISES

Вестник университета, 2016
In the article the analysis of features of calculation of index of potential intangible assets of the industrial enterprise as linear combinations of the quantitative values of each object of potential intangible assets and their weights.
I. Buzurnaya
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source