Results 191 to 200 of about 741,034 (292)

Editing Eden: CRISPR, the Image of God, and the Ethics of Genetic Intervention. [PDF]

Linacre Q
Oh JJ.
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Generative artificial intelligence in medical education: moving from potential to practice: when AI surpasses MDs. [PDF]

Can Med Educ J
Morjaria L, Sibbald M.
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence. [PDF]

Transl Psychiatry
Lannoy S, Bjork JM, Stephenson M, Sanchez-Roige S, Passero K, Edwards AC.   +5 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Strategic Thinking and Entrepreneurial Orientation as Drivers of Adaptive Resilience in Global Manufacturing SMEs: A Narrative Review of Dynamic Capabilities and Cross-Context Variations. [PDF]

F1000Res
Ongesa Nyamboga T.
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The street as transdisciplinary infrastructure: real world labs in One Urban Health-well-being corner shops in Québec, Canada. [PDF]

BMC Glob Public Health
de Leeuw E, Aenishaenslin C, Batal M, Beauchet O, Bouchard M, Boudreau LeBlanc A, Frohlich K, Kestens Y, Lord S, Potvin L, Terrat Y, Torres J, Trépanier M, Harriet N.   +13 more
europepmc   +1 more source

Paying for Suffering: the Problem of Human Experimentation [PDF]

, 1997
Palmer, Larry I.
core   +2 more sources