Results 191 to 200 of about 12,069,454 (281)

Mesenchymal Stromal Cells for Heart Diseases: Current Perspective and Future Directions. [PDF]

Biomolecules
Zajączkowski MA, Deptuła-Knioła M, Zawrzykraj-Motylińska M, Kaczyńska-Miotk A, Pikuła M, Kosiński A.   +5 more
europepmc   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Distinct risk profiles of heart failure and non-heart failure major adverse cardiovascular events among patients with early breast cancer: a competing-risk analysis. [PDF]

Int J Clin Oncol
Shigematsu H, Norishige A, Tanabe K, Sawatari H, Nakano Y, Amioka A, Okamoto D, Hino S, Ikejiri H, Sasada S, Okada M.   +10 more
europepmc   +1 more source

Zr Incorporation Into Lithium Nickel Oxides: Bulk or Surface Substitution?

Advanced Science, EarlyView.
Mechanism of Zr incorporation into lithium nickel oxide (LNO) cathodes is studied from atomistic to macroscale. Zr doping enhances cyclability of Li‐ion batteries with LNO via bulk, interface, and grain boundary optimization leading to structural integrity at atomistic‐ and micro‐scale of secondary particle aggregates.
Lars Winkler, Geon‐Tae Park, Liang‐Yin Kuo, Martin Ihrig, Konstantin Köster, Johan E. ten Elshof, Mark Huijben, Myoung‐Chan Kim, Min‐Gyu Seo, Yang‐Kook Sun, Payam Kaghazchi   +10 more
wiley   +1 more source

Dickkopf-3 (DKK3) in cardiovascular diseases: from a stress-responsive biomarker to a potential therapeutic target. [PDF]

Front Pharmacol
Fu X, Dai J, Wang X, Qiu L, Hua Y.
europepmc   +1 more source

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

Sodium-Glucose Cotransporter 2 Inhibitors in Valvular Heart Disease: Cardiovascular Benefit, Valve-Specific Effects, and Evidence Gaps-A Structured Narrative Review. [PDF]

J Clin Med
Rada M, Craciun ML, Pah AM, Hogea GS, Gurgus D, Velimirovici MD, Surducan DA, Mahmoud A, Utu D, Avram CA.   +9 more
europepmc   +1 more source

Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer

Advanced Science, EarlyView.
Incomplete microwave ablation (iMWA) induced a spatially organized, macrophage‐rich immunosuppressive tumor microenvironment (TME) in orthotopic VX2 liver tumors. Molecular MRI enhanced with europium‐doped very small superparamagnetic iron oxide nanoparticles (Eu‐VSOP) noninvasively visualized this remodeling, showing preferential nanoparticle ...
Yubei He, Han Xu, Julian M. M. Rogasch, Nikolaus Berndt, Jing Guo, Eyk Schellenberger, Akvile Häckel, Luisa Heidemann, Friederike Hesse, Yu Liu, Justus Ramtke, Nicola Beindorff, Frank Hofheinz, Avan Kader, Michael Mülleder, Kathrin Textoris‐Taube, Bernd Hamm, Dominik N. Müller, Robin Schmidt, Ralf Hauptmann, Heike Traub, Mathias Schannor, Lynn Jeanette Savic   +22 more
wiley   +1 more source

Curcumin in Fibrosis Treatment: A Review. [PDF]

Drug Des Devel Ther
Deng L, Liu X, Feng H, Zhang B, Yue R.
europepmc   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source