Results 51 to 60 of about 12,069,454 (281)

Interaction model between quercetin (3,5,7,3p,4p-pentahidroxiflavone) and human shock thermic factor (HFS)

Revista Cuarzo, 2017
INTRODUCTION. The expression of the HSP stress inducted are regulated by the Shock Thermic Factor (HSF), that exists in an inactive form as a monomer and when it becomes a trimer can make a bind to DNA activating the HSP transcription.OBJECTIVE. Design a computational model that helps elucidate possible interactions between quercetin fl avonoid and ...
Diana Carolina Clavijo B., Juvenal Yosa R., Orlando Acevedo S., Claudia Cifuentes, Carlos M Estévez Bretón   +4 more
openaire   +3 more sources

Optimizing Hydroxychloroquine Blood Levels and Long‐Term Hydroxychloroquine Intake Could Lower Atherosclerotic Cardiovascular Disease Risk and Prevent Polypharmacy in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is the cornerstone of systemic lupus erythematosus (SLE) management with benefits extending beyond SLE control, including protection against atherosclerotic cardiovascular disease (ASCVD). Although HCQ blood levels reflect recent exposure and long‐term intake reflects medication adherence, the impact of longitudinal ...
Shivani Garg, Murray Urowitz, Charlie Dentz, Niriti Adhikari, Fauzia Hollnagel, Nathalie Costedoat‐Chalumeau   +5 more
wiley   +1 more source

FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling

JCI Insight, 2022
Cardiac pathological remodeling, a primary contributor to heart failure (HF) and death, is an important target for HF therapy. However, the signaling pathways that govern cardiac remodeling are not fully elucidated.
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, Peng Yao   +3 more
doaj   +1 more source

Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro [PDF]

, 2001
Angiogenesis, the formation of a new blood supply, is an essential step in tumorigenesis. Although vascular endothelial growth factor (VEGF) is known to be a very potent angiogenic factor in most solid tumors, little is known about its production and ...
Losa, Marco, Lohrer, P., Gloddek, J., Renner, U., Lohrer, Penny, Uhl, E., Stalla, G., Pagotto, U., Hopfner, Ursula, Renner, Ulrich, Losa, Marc, Losa, M., Pagotto, Uberto, Gloddek, Jutta, Uhl, Eberhard, Stalla, Günter K., Hopfner, U.   +16 more
core   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among US Veterans

Arthritis Care &Research, EarlyView.
Biomedical research involving US veterans continues to advance health care beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both veteran ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

Nuclear Factor kappa B is required for the production of infectious human herpesvirus 8 virions

Frontiers in Microbiology, 2014
Human herpesvirus 8 (HHV8) infection leads to potent activation of nuclear factor kappa B (NFB) in primary and transformed cells. We used recombinant HHV8 (rKSHV.219) expressing green fluorescent protein under the constitutive cellular promoter ...
Negin N Blattman, Negin N Blattman, Michael eLagunoff, Lawrence eCorey, Lawrence eCorey   +4 more
doaj   +1 more source

Human factor relevance in safety assurance of railway operations

, 2014
This article aims to bring to the attention of European standard regulation bodies, the need of revaluing the importance of Human Factor (HF) in railway operation organizational processes.
R. Lamedica, L. Carlizza, B. Vittorini, G. Di Grazia, G. Fabbri, LAMEDICA, Regina   +5 more
core   +1 more source

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

Semaphorin 3F is elevated in serum of heart failure patients and inhibits cardiac angiogenesis via the VEGF/Akt/eNOS pathway

Journal of Molecular and Cellular Cardiology Plus
Left ventricular (LV) remodeling in heart failure (HF) is associated with vascular rarefaction and impaired angiogenesis. The inhibition of vascular endothelial growth factor (VEGF)-mediated angiogenesis is a key feature in the pathophysiology of HF ...
Diana Petrova, Miki Weberbauer, Stephanie Reichert, Stephanie Scheid, Jennifer Esser, Katrin Fink, Daniel Duerschmied, Martin Moser, Thomas Helbing   +8 more
doaj   +1 more source

Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction

Disease Models & Mechanisms, 2012
SUMMARY Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key
Melissa Touvron, Brigitte Escoubet, Mathias Mericskay, Aude Angelini, Luciane Lamotte, Maria Paola Santini, Nadia Rosenthal, Dominique Daegelen, David Tuil, Jean-François Decaux   +9 more
doaj   +1 more source