Results 41 to 50 of about 12,069,454 (281)

The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

PLoS ONE, 2016
Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of ...
Carola I F Janssen, Diane Jansen, Martina P C Mutsaers, Pieter J W C Dederen, Bram Geenen, Monique T Mulder, Amanda J Kiliaan   +6 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

HEART FAILURE IN PEOPLE WITH HIV

American Journal of Preventive Cardiology, 2023
Therapeutic Area: Heart Failure Background: People with human immunodeficiency virus (PWH) have an improved life expectancy because of the wide availability of antiretroviral therapy (ART), resulting in an increased prevalence of heart failure (HF ...
Karla L. Inestroza, Vanessa Hurtado, Michaela E. Larson, Bertrand F. Ebner, Jelani Kayode Grant, Louis Vincent, Maria Alcaide, Barry Hurwitz, Catherine Boulanger, Alexis Powell, Dushyantha Jayaweera, Claudia A. Martinez   +11 more
doaj   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

Impact of Aldosterone on the Failing Myocardium: Insights from Mitochondria and Adrenergic Receptors Signaling and Function

Cells, 2021
The mineralocorticoid aldosterone regulates electrolyte and blood volume homeostasis, but it also adversely modulates the structure and function of the chronically failing heart, through its elevated production in chronic human post-myocardial infarction
Mariona Guitart-Mampel, Pedro Urquiza, Jordana I. Borges, Anastasios Lymperopoulos, Maria E. Solesio   +4 more
doaj   +1 more source

Systems Intelligence and the HF Tool in foregrounding human factors in systemic safety

Theoretical Issues in Ergonomics Science
The safety of sociotechnical systems ultimately depends on the success of people’s everyday activities at work. This is the core idea of Safety-II. However, practical tools for applying Safety-II thinking in practice are scarce. In this study we present a new approach to managing human factors (HF) in safety, spotlighting people’s own experiential and ...
Saarinen Esa, Hämäläinen Raimo P., Teperi Anna-Maria, Juvonen Riitta   +3 more
openaire   +2 more sources

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham, Hannah F. Brubeck, Aaron Baraff, Punyasha Roul, Namrata Singh, James S. Andrews, Grant W. Cannon, Gary A. Kunkel, Ted R. Mikuls, Bryant R. England, Dolores M. Shoback, Patricia P. Katz, Jose M. Garcia, Ariela R. Orkaby, Joshua F. Baker   +14 more
wiley   +1 more source

Human factors design methods review

, 2003
This report describes the human factors (HF) design methods review that was conducted as part of work package 1.3. 2-Design methods review, and is part of work package 1,'Human Factors Integration for C4i Systems'. The overall aim of work package 1.3.
Stanton, Neville A., Walker, G, Salmon, P   +2 more
core   +1 more source

Study on Human Integrity Management System Maturity Level for Supporting Asset Integrity and Process Safety Implementation

Journal of Materials Exploration and Findings
The human factors (HF) are recognized as one of critical process safety barriers involved in normal and abnormal conditions in the oil and gas industry.
Anggiat M. Sihotang, Dedi Priadi, D. Rizal Asral   +2 more
doaj   +1 more source