Results 41 to 50 of about 87,309 (258)

Study on Human Integrity Management System Maturity Level for Supporting Asset Integrity and Process Safety Implementation

Journal of Materials Exploration and Findings
The human factors (HF) are recognized as one of critical process safety barriers involved in normal and abnormal conditions in the oil and gas industry.
Anggiat M. Sihotang, Dedi Priadi, D. Rizal Asral   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling

JCI Insight, 2022
Cardiac pathological remodeling, a primary contributor to heart failure (HF) and death, is an important target for HF therapy. However, the signaling pathways that govern cardiac remodeling are not fully elucidated.
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, Peng Yao   +3 more
doaj   +1 more source

Expression of biologically active human clotting factor IX (hF IX) in the mammary gland of transgenic mice

Chinese Science Bulletin, 1998
The DNA of human factor IX (hF IX) gene vector pMC IX m, which had been proven to be able to express inin vitro and living cells, was introduced into 586 zygotes of Kunming Whlte Mice by positive pressure microinjection technique with manual operation.
Ying Huang, Kezhong Zhang, Wenying Huang, Daru Lu, Ying Huang, Zhanlu Ma, Zhaorui Ren, Xinfang Qiu, Jinglun Xue, Yitao Zeng, Shuzhen Huang   +10 more
openaire   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Semaphorin 3F is elevated in serum of heart failure patients and inhibits cardiac angiogenesis via the VEGF/Akt/eNOS pathway

Journal of Molecular and Cellular Cardiology Plus
Left ventricular (LV) remodeling in heart failure (HF) is associated with vascular rarefaction and impaired angiogenesis. The inhibition of vascular endothelial growth factor (VEGF)-mediated angiogenesis is a key feature in the pathophysiology of HF ...
Diana Petrova, Miki Weberbauer, Stephanie Reichert, Stephanie Scheid, Jennifer Esser, Katrin Fink, Daniel Duerschmied, Martin Moser, Thomas Helbing   +8 more
doaj   +1 more source

Nuclear Factor kappa B is required for the production of infectious human herpesvirus 8 virions

Frontiers in Microbiology, 2014
Human herpesvirus 8 (HHV8) infection leads to potent activation of nuclear factor kappa B (NFB) in primary and transformed cells. We used recombinant HHV8 (rKSHV.219) expressing green fluorescent protein under the constitutive cellular promoter ...
Negin N Blattman, Negin N Blattman, Michael eLagunoff, Lawrence eCorey, Lawrence eCorey   +4 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction

Disease Models & Mechanisms, 2012
SUMMARY Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key
Melissa Touvron, Brigitte Escoubet, Mathias Mericskay, Aude Angelini, Luciane Lamotte, Maria Paola Santini, Nadia Rosenthal, Dominique Daegelen, David Tuil, Jean-François Decaux   +9 more
doaj   +1 more source