Results 71 to 80 of about 1,734,834 (239)

Human Immunodeficiency Virus Infection and Variation in Heart Failure Risk by Age, Sex, and Ethnicity: The HIV HEART Study.

Mayo Clinic proceedings, 2021
OBJECTIVES To evaluate the risk of heart failure (HF) linked to human immunodeficiency virus (HIV) infection, how risk varies by demographic characteristics, and whether it is explained by atherosclerotic disease or risk factor treatment.
A. S. Go, K. Reynolds, Harshith R. Avula, W. Towner, R. Hechter, M. Horberg, S. Vupputuri, T. Leong, W. Leyden, T. Harrison, Keane K. Lee, S. Sung, M. Silverberg   +12 more
semanticscholar   +1 more source

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]

, 2019
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A., Bernstein, Daniel, Brandimarto, Jeff, Cappola, Thomas, Chang, Alex C., Chin, Elizabeth T., Connolly, Andrew, Cordero, Pablo, Depaoli-Roach, Anna A., Dewey, Frederick, Erbilgin, Ayca, Glazer, Nicole, Gloudemans, Michael J., Hakonarson, Hakon, Hannenhalli, Sridhar, Huang, Yong, Li, Hongzhe, Li, Mingyao, Lusis, Aldons J., Malloy, Christine, Margulies, Kenneth B., Montgomery, Stephen B., Moravec, Christine S., Morley, Michael, Parikh, Victoria N., Pavlovic, Aleksandra, Ritter, Scott, Shang, Ching, Skreen, Jamie, Smith, Kevin S., Tang, W. H. Wilson, Waggott, Daryl, Wheeler, Matthew T., Zaleta, Kathia, Zhao, Mingming   +34 more
core   +2 more sources

Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes

Diabetes, 2021
Patients with diabetes have an increased risk of heart failure (HF). Diabetes is highly prevalent in HF with preserved ejection fraction (HFpEF), which is on the rise worldwide. The role of diabetes in HF is less established, and available treatments for
D. M. Cibi, Reddemma Sandireddy, Hanumakumar Bogireddi, Nicole G. Z. Tee, Siti Aishah Binte Abdul Ghani, B. Singh, N. Mackman, Manvendra K. Singh, Anamika Singh   +8 more
semanticscholar   +1 more source

Study on Human Integrity Management System Maturity Level for Supporting Asset Integrity and Process Safety Implementation

Journal of Materials Exploration and Findings
The human factors (HF) are recognized as one of critical process safety barriers involved in normal and abnormal conditions in the oil and gas industry.
Anggiat M. Sihotang, Dedi Priadi, D. Rizal Asral   +2 more
doaj   +1 more source

Chronic heart failure is characterized by altered mitochondrial function and structure in circulating leucocytes [PDF]

, 2018
Oxidative stress is currently viewed as a key factor in the genesis and progression of Heart Failure (HF). The aim of this study was to characterize the mitochondrial changes linked to oxidative stress generation in circulating peripheral blood ...
Coluccia, Roberta, Gallo, Giovanna, Micaloni, Andrea, Pagannone, Erika, Raffa, Salvatore, Ranieri, Danilo, Rubattu, Speranza, Salerno, Gerardo, Scrofani, Cristina, Testa, Marco, Torrisi, Maria Rosaria, Valente, Sabatino, Volpe, Massimo   +12 more
core   +1 more source

Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy

Nature Communications, 2020
Poor access to human left ventricular myocardium is a significant limitation in the study of heart failure (HF). Here, we utilise a carefully procured large human heart biobank of cryopreserved left ventricular myocardium to obtain direct molecular ...
Mengbo Li, B. Parker, E. Pearson, Benjamin Hunter, Jacob Y Cao, Y. Koay, O. Guneratne, D. James, Jean Y. H. Yang, S. Lal, J. O’Sullivan   +10 more
semanticscholar   +1 more source

Normal versus pathological cardiac fibroblast-derived extracellular matrix differentially modulates cardiosphere-derived cell paracrine properties and commitment [PDF]

, 2017
Human resident cardiac progenitor cells (CPCs) isolated as cardiosphere-derived cells (CDCs) are under clinical evaluation as a therapeutic product for cardiac regenerative medicine.
Angelini, Francesco, BIONDI ZOCCAI, Giuseppe, Castaldo, Clotilde, Chimenti, Isotta, Frati, Giacomo, Maiello, Ciro, Meglio, Franca di, Messina, Elisa, Nurzynska, Daria, Pagano, Francesca, Picchio, Vittorio, Sciarretta, Sebastiano   +11 more
core   +3 more sources

Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-activated Protein Kinase-α - Proliferator-Activated Receptor-r Coactivator-1α Signaling in Skeletal Muscle of Mice With Heart Failure.

Circulation: Heart Failure, 2020
BACKGROUND We recently reported that treatment with rhBDNF (recombinant human brain-derived neurotrophic factor) improved the reduced exercise capacity of mice with heart failure (HF) after myocardial infarction (MI).
J. Matsumoto, S. Takada, T. Furihata, Hideo Nambu, Naoya Kakutani, Satoshi Maekawa, Wataru Mizushima, Ippei Nakano, A. Fukushima, T. Yokota, S. Tanaka, Haruka Handa, H. Sabe, S. Kinugawa   +13 more
semanticscholar   +1 more source

FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling

JCI Insight, 2022
Cardiac pathological remodeling, a primary contributor to heart failure (HF) and death, is an important target for HF therapy. However, the signaling pathways that govern cardiac remodeling are not fully elucidated.
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, Peng Yao   +3 more
doaj   +1 more source

Rabbit models of heart disease. [PDF]

, 2008
Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeutic strategies ...
Bers, Donald M, Pogwizd, Steven M
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