Results 91 to 100 of about 26,756,178 (360)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Human Factors in Surgical Oncology

, 2020
In this chapter, we highlight the human factors approach to care in the cancer patient population. We review the impact of human factors in patients undergoing surgery for cancer and focus on ways to prevent any adverse consequences of these elements ...
Crystal, Jessica S., Gangi, Alexandra, Alexandra Gangi, Jessica S. Crystal   +3 more
core   +1 more source

Modality-specific organization in the representation of sensorimotor sequences

Frontiers in Psychology, 2013
Sensorimotor representations of movement sequences are hierarchically organized. Here we test the effects of different stimulus modalities on such organizations.
Arnaud eBoutin, Cristina eMassen, Herbert eHeuer   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Interpretive phenomenological analysis (IPA) of organisational factors related to maintenance reliability in a petroleum production workplace

, 2013
Aim: To understand the influence of organisational factors on workplace effectiveness in petroleum processing operations based on perceptions of maintenance technicians. Background: Numerous engineering measures exist for determining the effectiveness of
Straker, Leon M., Antonovsky, Ari, Pollock, Clare M. (R20416), Straker, Leon, Antonovsky, A., Pollock, C.   +5 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The neural basis of attentional selection in goal-directed memory retrieval

Scientific Reports
Goal-directed memory reactivation involves retrieving the most relevant information for the current behavioral goal. Previous research has linked this process to activations in the fronto-parietal network, but the underlying neurocognitive mechanism ...
Melinda Sabo, Edmund Wascher, Daniel Schneider   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Infrastructural and human factors affecting safety outcomes of cyclists

, 2018
The increasing number of registered road crashes involving cyclists during the last decade and the high proportion of road crashes resulting in severe injuries and fatalities among cyclists constitutes a global issue for community health, urban ...
S. Useche, Luis Montoro, Francisco Alonso, Oscar Oviedo-Trespalacios   +3 more
semanticscholar   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source