Results 91 to 100 of about 4,017,875 (268)

Changes of cognitive functions and proinflammatory cytokines across the lifespan in latent Toxoplasma gondii infection

open access: yesBrain, Behavior, & Immunity - Health
Background: Recent findings showed serious consequences of latent T. gondii infection on the central nervous system, leading to psychiatric, immunological and cognitive impairments.
Patrick D. Gajewski   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Convolutional Neural Network as a Potential Tool for Camouflage Assessment

open access: yesApplied Sciences
Camouflage evaluation is traditionally evaluated through human visual search and detection experiments, which are time-consuming and resource intensive.
Erik Van der Burg   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study

open access: yesTranslational Psychiatry
A growing body of research highlights the fear extinction model as a key framework for understanding the pathology of anxiety disorders and developing therapeutic interventions.
Harleen Chhabra   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Patient-Centric Design of the Lonapegsomatropin Auto-Injector for Growth Hormone Deficiency: Usability Validation of Safe and Effective Use

open access: yesMedical Devices: Evidence and Research
Michael Lau,1 Paul Erik Fabricius,2 Nils Berg Madsen,3 Henrik Egesborg,3 Josephine Jensen3 1Human Factors Engineering, Insight by Nemera, Chicago, IL, USA; 2Industrial Design and HFE, Phillips-Medisize A/S, Struer, Denmark; 3Device Development, Ascendis ...
Lau M   +4 more
doaj  

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

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