Results 31 to 40 of about 7,485,808 (284)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Entrepreneurship, innovation, and human flourishing [PDF]

Small Business Economics, 2014
This essay uses Edmund Phelps’ new book Mass Flourishing: How Grassroots Innovation Created Jobs, Challenge, and Change (Phelps 2013) as inspiration to discuss innovation and entrepreneurship. The book is laudable for its discussion of what constitutes a “good life”.
openaire   +1 more source

Education and the Human Good [PDF]

, 2011
What kind of reasons can be given for believing education is valuable? One can regard education as initiation into practices and refer to the goods internal to practices, but this does not objectively anchor claims about the goodness of education.
Curren, Randall
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Childhood antecedents of adult place satisfaction in 22 countries

Scientific Reports
We examine how childhood predictors—including retrospectively reported familial relationships, socioeconomic status, health, and religious activities—potentially influence satisfaction with the area or city where one lives (i.e., place satisfaction) in ...
Victor Counted, Dorota Weziak-Bialowolska, Richard G. Cowden, Byron R. Johnson, Tyler J. VanderWeele   +4 more
doaj   +1 more source

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham, Hannah F. Brubeck, Aaron Baraff, Punyasha Roul, Namrata Singh, James S. Andrews, Grant W. Cannon, Gary A. Kunkel, Ted R. Mikuls, Bryant R. England, Dolores M. Shoback, Patricia P. Katz, Jose M. Garcia, Ariela R. Orkaby, Joshua F. Baker   +14 more
wiley   +1 more source

Longitudinal associations of dispositional forgivingness with multidimensional well-being: a two-wave outcome-wide analysis in the Global Flourishing Study

npj Mental Health Research
In this preregistered longitudinal study with nationally representative samples from 23 countries in the Global Flourishing Study (N = 207,919), we examine associations between dispositional forgivingness and multidimensional well-being outcomes ...
Richard G. Cowden, Everett L. Worthington, R. Noah Padgett, Chris Felton, Dorota Weziak-Bialowolska, Renae Wilkinson, Katherine Jackson-Meyer, Zhuo J. Chen, Matt Bradshaw, Byron R. Johnson, Tyler J. VanderWeele   +10 more
doaj   +1 more source

Determinants of Body Mass Index in Early Systemic Sclerosis: Implications for Nutritional Risk Stratification

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal (GI) involvement can lead to malnutrition in patients with systemic sclerosis (SSc). Body mass index (BMI) remains the most widely used marker to screen nutritional status. We aimed to identify predictors of lower BMI in patients with SSc. Methods Patients with SSc from a prospective US cohort meeting 2013 American College of
Ali Y. Ayla, Meng Zhang, Bingrui Chen, Claudia Pedroza, Brian Skaug, Maureen Mayes, Michael Hughes, Shervin Assassi, Zsuzsanna H. McMahan   +8 more
wiley   +1 more source

Early life experiences and adult orientation to promote good in 22 countries

Scientific Reports
Prior research suggests associations between character involving an orientation to promote good (i.e., a disposition to take actions that contribute to the good of oneself and others) and improved well-being outcomes.
Ying Chen, Eric S. Kim, Julia S. Nakamura, Dorota Weziak-Bialowolska, Renae Wilkinson, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +7 more
doaj   +1 more source

Human Flourishing, Human Dignity, and Human Rights

, 2015
Rather than treating them as discrete and incommensurable ideas, we sketch some connections between human flourishing and human dignity, and link them to human rights.
Evans, Nicholas, Kleinig, John
core   +1 more source