Results 51 to 60 of about 23,258 (293)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Early life experiences and adult orientation to promote good in 22 countries

Scientific Reports
Prior research suggests associations between character involving an orientation to promote good (i.e., a disposition to take actions that contribute to the good of oneself and others) and improved well-being outcomes.
Ying Chen, Eric S. Kim, Julia S. Nakamura, Dorota Weziak-Bialowolska, Renae Wilkinson, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +7 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Identifying childhood correlates of adult purpose and meaning across 22 countries (Global Flourishing Study)

npj Mental Health Research
How might we cultivate a life imbued with purpose and meaning? Though common experience indicates purpose and meaning are inherently important, empirical evidence confirms they are also linked to improved health/well-being. However, childhood antecedents
Eric S. Kim, Matt Bradshaw, R. Noah Padgett, Ying Chen, Koichiro Shiba, James L. Ritchie-Dunham, Brendan W. Case, Byron R. Johnson, Tyler J. VanderWeele   +8 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Childhood experiences and adult self-rated physical health in 22 countries

BMC Global and Public Health
Background Relatively little research has examined the associations between childhood experiences and subsequent adult self-rated health in diverse countries and cultures around the world using nationally representative data.
Matt Bradshaw, Blake Victor Kent, Jennifer Susan Wortham, Noémie Le Pertel, Tyler J. VanderWeele, Byron R. Johnson   +5 more
doaj   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Sociodemographic variation and childhood predictors of showing love and care for others in 22 countries

Scientific Reports
Showing love and care for other people is a vital aspect of human relationships. However, little is known about how levels of love/care expression differ across cultures and across sociodemographic groups within those different cultures, or about the ...
Matthew T. Lee, Renae Wilkinson, Katelyn N. G. Long, Brendan W. Case, James L. Ritchie-Dunham, Matt Bradshaw, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +8 more
doaj   +1 more source