Results 61 to 70 of about 7,485,808 (284)

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Childhood predictors of religious reading: a cross-national analysis in the Global Flourishing Study

Scientific Reports
While the family environment, including parental religiosity, shapes children’s religious behaviors, evidence concerning factors influencing religious reading and listening (RR/L) in adulthood remains scarce.
Dorota Weziak-Bialowolska, Richard G. Cowden, Piotr Bialowolski, Matt Bradshaw, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +6 more
doaj   +1 more source

Atmospheric Water Harvesting Through Polymer Hydrogel Sorbents: Materials Chemistry, Design Strategies, and Applications

Advanced Science, EarlyView.
Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta, Sushmit Sen, Nilanjan Dey, Amrita Chatterjee, Ananya Sadhu, Sudipta Sarkar, Pradip K. Maji   +6 more
wiley   +1 more source

Medical tourism among Indonesians: a scoping review

BMC Health Services Research
Background International medical travel or medical tourism is not a new phenomenon in many countries, including among Indonesians. Indonesia is reported as a major source of patients from the lower, middle, to upper classes for its neighbouring countries.
Gregorius Abanit Asa, Nelsensius Klau Fauk, Caitlan McLean, Paul Russell Ward   +3 more
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Childhood predictors of suffering in adulthood across 22 countries

Communications Medicine
Background Evidence suggests that suffering may degrade health and well-being. However, further research is needed to identify potential targets for addressing population-level suffering.
Richard G. Cowden, Zhuo Job Chen, Renae Wilkinson, Dorota Weziak-Bialowolska, Thomas Breedlove, Craig Gundersen, Koichiro Shiba, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +9 more
doaj   +1 more source

Human Flourishing from a Complex Adaptive System Perspective: Exploring the Wellbeing of Social Groups as Emergent Entities

Social Sciences
Can qualities of wellbeing and flourishing be meaningfully applied at the level of the social group, not merely as an aggregation of the wellbeing or flourishing of its members, but on its own terms as an emergent entity? This paper proposes that this is
Tim Lomas, Dennis Snower, James O. Pawelski, Brendan W. Case, Matthew T. Lee, Jonathan D. Teubner, Tyler J. VanderWeele   +6 more
doaj   +1 more source

Emotional Congruence and Judgments of Honesty and Bias

Collabra: Psychology, 2018
Psychological and philosophical discussions typically understand honesty as reporting truth with propositional statements. In this model, emotions are often seen as irrelevant or a hindrance to honesty, because they can bias our reports.
Alexander F. Danvers, Jing I. Hu, Makenzie J. O'Neil   +2 more
doaj   +1 more source

Mechanically Robust, Self‐Healable, and Cryotolerant GelMA Hydrogel for Wearable Tactile Sensors with Enhanced Durability, Lifetime, and Environmental Stability

Advanced Science, EarlyView.
A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li, Gengyu Han, Boqing Jia, Jijian Lu, Changxu Zhang, Bin Wang, Jiaxiang Wang, Kang Zhao, Muhammad Afzal Khan Qureshi, Lan Yu, Min Li, Guoxi Luo, Tong Wang, Qijing Lin, Weishi Li, Libo Zhao, Yumeng Xue   +16 more
wiley   +1 more source