Results 71 to 80 of about 1,631,641 (306)

Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian, Robert U. Newton, Dennis R. Taaffe, Nicholas G. Gottardo, Santosh Valvi, Carolyn J. Peddle‐McIntyre, Jodie Cochrane Wilkie, Daniel A. Galvão   +7 more
wiley   +1 more source

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

Cell & Bioscience, 2020
Background The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype.
Thanakorn Pungsrinont, Malika Franziska Sutter, Maren C. C. M. Ertingshausen, Gopinath Lakshmana, Miriam Kokal, Amir Saeed Khan, Aria Baniahmad   +6 more
doaj   +1 more source

Human ecological genetics

Ecological genetics, 2003
A resumptive review of the three types of effects of new environmental factors on human heredity is presented: 1) alteration of hereditary elements (induced mutagenesis); 2) pathological manifestations of gene expression on the specific environmental factors (ecogenetic diseases, pharmacogenetics, toxicogenomics, nutrigenomics); 3) alteration of the ...
openaire   +3 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Genome-wide methylation detection and episignature analysis using PacBio long-read sequencing

Genome Medicine
Background The detection of 5-methylcytosine (5mC) patterns in the human genome is relevant for the diagnosis of various genetic conditions. Genome-wide methylation episignatures provide a new approach for resolving variants of uncertain significance ...
Véronique Ivashchenko, Michelle de Groot, Ronny Derks, Amber den Ouden, Gelana Khazeeva, Simone van den Heuvel, Raoul Timmermans, Jordi Corominas Galbany, Rolph Pfundt, Tom Hofste, Helger Yntema, Lisenka Vissers, Alexander Hoischen, Juliet Hampstead, Christian Gilissen   +14 more
doaj   +1 more source

A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

Nature Communications, 2021
Many genetic loci have been linked to obesity, but knowledge of their functional mechanisms is limited. Here, the authors perform reporter assays and temporal functional genomics data generation to characterize obesity genetic loci and find that loci ...
Amelia C. Joslin, Débora R. Sobreira, Grace T. Hansen, Noboru J. Sakabe, Ivy Aneas, Lindsey E. Montefiori, Kathryn M. Farris, Jing Gu, Donna M. Lehman, Carole Ober, Xin He, Marcelo A. Nóbrega   +11 more
doaj   +1 more source

Increasing power for voxel-wise genome-wide association studies : the random field theory, least square kernel machines and fast permutation procedures [PDF]

, 2012
Imaging traits are thought to have more direct links to genetic variation than diagnostic measures based on cognitive or clinical assessments and provide a powerful substrate to examine the influence of genetics on human brains. Although imaging genetics
Feng, Jianfeng, Ge, Tian, Hibar, Derrek P., Nichols, Thomas E., Thompson, Paul M.   +4 more
core   +1 more source

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

H3K36 Methylation as a Guardian of Epigenome Integrity

Nature Communications
H3K36 methylation is a key epigenetic mark with critical roles in development and disease. Here, we systematically dissect its functions using CRISPR-engineered mouse mesenchymal stem cells lacking combinations of the five H3K36 methyltransferases ...
Reinnier Padilla, Gerry A. Shipman, Cynthia Horth, Michel Gravel, Eric Bareke, Jacek Majewski   +5 more
doaj   +1 more source