Results 71 to 80 of about 884,084 (316)

H3K36 Methylation as a Guardian of Epigenome Integrity

Nature Communications
H3K36 methylation is a key epigenetic mark with critical roles in development and disease. Here, we systematically dissect its functions using CRISPR-engineered mouse mesenchymal stem cells lacking combinations of the five H3K36 methyltransferases ...
Reinnier Padilla, Gerry A. Shipman, Cynthia Horth, Michel Gravel, Eric Bareke, Jacek Majewski   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Microdeletions and molecular genetics

, 2004
Educational Items on Microdeletions and molecular ...
Fryns, JP, A Vogels, JP Fryns, Vogels, A
core   +1 more source

Imaging genetics of FOXP2 in dyslexia

, 2022
S.224-229Dyslexia is a developmental disorder characterised by extensive difficulties in the acquisition of reading or spelling. Genetic influence is estimated at 50-70%.
Wolf, C., Quente, E., Cichon, S., Alexander, M., Becker, A., Wilcke, A., Müller-Myhsok, B., Ligges, C., Burkhardt, J., Hoffmann, P., Kirsten, H., Boltze, J., Ahnert, P.   +12 more
core   +1 more source

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

Cell & Bioscience, 2020
Background The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype.
Thanakorn Pungsrinont, Malika Franziska Sutter, Maren C. C. M. Ertingshausen, Gopinath Lakshmana, Miriam Kokal, Amir Saeed Khan, Aria Baniahmad   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Medicine in the Beehive State: Chapter 38: Human genetics

, 1992
This is a chapter on the history of the Department of Human Genetics at the University of Utah taken from the book, Medicine in the Beehive State, 1940-1990, edited by Henry P.
Leppert, Mark F., Gesteland, Raymond F.
core  

Drosophila Toxicogenomics: genetic variation and sexual dimorphism in susceptibility to 4-Methylimidazole

Human Genomics
Background 4-methylimidazole is a ubiquitous and potentially carcinogenic environmental toxicant. Genetic factors that contribute to variation in susceptibility to its toxic effects are challenging to assess in human populations.
Katelynne M. Collins, Elisabeth Howansky, Sarah C. Macon-Foley, Maria E. Adonay, Vijay Shankar, Richard F. Lyman, Nestor Octavio Nazario-Yepiz, Jordyn K. Brooks, Rachel A. Lyman, Trudy F. C. Mackay, Robert R. H. Anholt   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

ASHG Position Statement : The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results [PDF]

, 2019
© 2019 American Society of Human Genetics. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 6 month embargo from ...
Rehm, Heidi L., Nelson, Tanya N, Brothers, Kyle B., Fitzgerald-Butt, Sara, Jarvik, Gail P., Wagner, Jennifer K, Ormond, Kelly E., Vassy, Jason L, Garrison, Nanibaa' A, Jamal, Leila, Jarvik, Gail P, Levy, Howard P, McCormick, Jennifer B, Richer, Julie, Nelson, Tanya N., Garrison, Nanibaa’ A., McCormick, Jennifer B., Rehm, Heidi L, Vassy, Jason L., Ormond, Kelly E, Wagner, Jennifer K., Souzeau, Emmanuelle, Bombard, Yvonne, Brothers, Kyle B, James, Cynthia A, Levy, Howard P., James, Cynthia A.   +26 more
core   +1 more source