Results 91 to 100 of about 884,084 (316)

Proteomic profiling of the plasma of Gambian children with cerebral malaria

Malaria Journal, 2018
Background Cerebral malaria (CM) is a severe neurological complication of Plasmodium falciparum infection. A number of pathological findings have been correlated with pediatric CM including sequestration, platelet accumulation, petechial haemorrhage and ...
Ehab M. Moussa, Honglei Huang, Marie L. Thézénas, Roman Fischer, Abhinay Ramaprasad, Fatou Sisay-Joof, Muminatou Jallow, Arnab Pain, Dominic Kwiatkowski, Benedikt M. Kessler, Climent Casals-Pascual   +10 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Phase I and Phase II planning statement for a Department of Human Genetics

, 1981
memorandumThis is the March, 1981 memorandum to University of Utah vice-president Chase Peterson detailing the need and a plan for creating a coordinated human genetics ...
Skolnick, Mark
core  

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Hypomorphic Mutations in the Central Fanconi Anemia Gene FANCD2 Sustain a Significant Group of FA-D2 Patients with Severe Phenotype. Running title : FA-D2 phenotype and FANCD2 mutations

, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008FANCD2 is an evolutionarily conserved Fanconi anemia (FA) gene that plays a central role in DNA double-strand type damage responses.
Detlev Schindler, Casado, José A., Surrallés, Jordi, Bueren, Juan, Schindler, Detlev, Arleen D. Auerbach, Holger Hoehn, Schneider, Hildegard, Kornelia Neveling, Elsa Callén, Kalba, Reinhard, Berwick, Marianne, Jean Soulier, Hunt, Curtis, Pals, Gerard, Rosalina van Spaendonk, Gluckman, Eliane, Callén Moréu, Elsa, Joenje, Hans, Kalb, Reinhard, Batish, Sat Dev, Soulier, Jean, Juan Bueren, Hanenberg, Helmut, Helmut Hanenberg, C. Michel Zwaan, Linka, Yvonne, Winter, Johan P. de, Eliane Gluckman, Neveling, Kornelia, Yvonne Linka, Hans Joenje, Markus Grompe, Johan P. de Winter, Grompe, Markus, Zwaan, C. Michel, Surrallés i Calonge, Jordi, Reinhard Kalb, Hoehn, Holger, Auerbach, Arleen D., Jordi Surrallés, Ángeles Dasí, de Winter, Johan P., Dasí, Ángeles, Marianne Berwick, José A. Casado, Sat Dev Batish, Curtis Hunt, Van Spaendonk, Rosalina, Callén, Elsa, Hildegard Schneider, Batishb, Sat Dev, Gerard Pals   +52 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Report on the ethical, legal, economic and social implications of human genetics by the temporary committee on human genetics and other new technologies in modern medicine: changes recommended by the European Society of Human Genetics

, 2001
of the European ...
European Society of Human Genetics [ESHG]
core  

The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy. [PDF]

, 2019
Sudden cardiac death (SCD) is often associated with structural abnormalities of the heart during autopsy. This study sought to compare the diagnostic yield of postmortem genetic testing in (1) cases with structural findings of uncertain significance at ...
Raju, Hariharan, Rafik Tadros, Greg Mellor, Mary N. Sheppard, Jackie Crawford, Marta Cohen, Cook, SA, Chris Miles, Sheppard, MN, Bezzina, CR, Govind, Risha, James S. Ware, Winkel, Bo G, Love, Donald R, Lodder, Elisabeth M., Cook, Stuart A, Govind, R, Risha Govind, Ware, James S., Papadakis, Michael, Tfelt-Hansen, Jacob, Lahrouchi, Najim, Skinner, Jonathan R, Ware, JS, Michael Papadakis, Cook, Stuart A., Christian van der Werf, Love, DR, Donald R. Love, Bee Y. Soh, Jacob Tfelt-Hansen, van der Werf, Christian, Sharma, S, Lodder, Elisabeth M, Till, Janice, Cohen, Marta, van der Werf, C, Bo G. Winkel, Skinner, Jonathan R., Chee J. Pua, Wilde, Arthur AM, Maria Tome-Esteban, Raju, H, Tome-Esteban, M, Bhalshankar, Jaydutt D, Tadros, R, Mellor, G, Crawford, Jackie, Sharma, Sanjay, Lodder, EM, Connie R. Bezzina, Papatheodorou, Stathis, Cole, Della, Arthur A. M. Wilde, Miles, Chris, Miles, C, Love, Donald R., Wilde, Arthur A. M., Tadros, Rafik, Della Cole, Hariharan Raju, Lahrouchi, N, Wilde, AAM, Stuart A. Cook, Mellor, Greg, Wilde, Arthur A M, Wijeyeratne, Yanushi D, Papatheodorou, S, Wijeyeratne, YD, Winkel, BG, Pua, Chee J, Pua, CJ, Behr, Elijah R, Tfelt-Hansen, J, Ware, James S, Wijeyeratne, Yanushi D., Till, J, Janice Till, Stathis Papatheodorou, Jaydutt D. Bhalshankar, Bhalshankar, JD, Cohen, M, Sheppard, Mary N., Winkel, Bo G., Bezzina, Connie R., Soh, Bee Y, Tome-Esteban, Maria, Pua, Chee J., Crawford, J, Skinner, JR, Bhalshankar, Jaydutt D., Yanushi D. Wijeyeratne, Sanjay Sharma, Sheppard, Mary N, Bezzina, Connie R, Cole, D, Behr, Elijah R., Papadakis, M, Elijah R. Behr, Jonathan R. Skinner, Soh, BY, Najim Lahrouchi, Soh, Bee Y., Behr, ER, Elisabeth M. Lodder   +104 more
core   +1 more source