Results 91 to 100 of about 10,524,108 (363)

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

Cell & Bioscience, 2020
Background The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype.
Thanakorn Pungsrinont, Malika Franziska Sutter, Maren C. C. M. Ertingshausen, Gopinath Lakshmana, Miriam Kokal, Amir Saeed Khan, Aria Baniahmad   +6 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Personalized and graph genomes reveal missing signal in epigenomic data

Genome Biology, 2020
Background Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome, we hypothesize that using a ...
Cristian Groza, Tony Kwan, Nicole Soranzo, Tomi Pastinen, Guillaume Bourque   +4 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Time to Diagnosis Among Children and Adolescents With Cancer in Québec, Canada: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen, Ronald D. Barr, Erin Strumpf, Mariam El‐Zein, Eduardo L. Franco, Talía Malagón   +5 more
wiley   +1 more source

Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank

Nature Genetics, 2021
J. Szustakowski, S. Balasubramanian, E. Kvikstad, Shareef Khalid, Paola G. Bronson, Ariella Sasson, Emily Wong, Daren Liu, J. Wade Davis, C. Haefliger, A. Katrina Loomis, Rajesh Mikkilineni, H. J. Noh, Samir Wadhawan, X. Bai, A. Hawes, O. Krasheninina, Ricardo Ulloa, Alexander Lopez, E. Smith, Jeffrey Waring, Christopher D. Whelan, Ellen A. Tsai, J. Overton, W. Salerno, H. Jacob, S. Szalma, H. Runz, Gregory Hinkle, P. Nioi, S. Petrovski, Melissa R. Miller, A. Baras, L. Mitnaul, J. Reid, Oleg Carlos Saurabh Goncalo Nilanjana Christina Boris M Moiseyenko Rios Saha Abecasis Banerjee Beechert Bo, O. Moiseyenko, C. Ríos, Saurabh Saha, Gonçalo R. Abecasis, N. Banerjee, Christina Beechert, Boris Boutkov, M. Cantor, G. Coppola, A. Economides, Gisu Eom, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, L. Habegger, Marcus Jones, R. Lanche, Michael Lattari, M. Leblanc, Dadong Li, L. Lotta, Kia Manoochehri, A. Mansfield, Evan K. Maxwell, Jason Mighty, Mrunali Nafde, S. O’Keeffe, Max Orelus, Maria Sotiropoulos Padilla, R. Panea, Tommy Polanco, Manasi Pradhan, A. Rasool, T. Schleicher, Deepika Sharma, A. Shuldiner, J. Staples, C. V. van Hout, Louis Widom, Sarah E. Wolf, Sally John, Chia-Yen Chen, David Sexton, V. Kupelian, E. Marshall, Timothy Swan, Susan Eaton, Jimmy Liu, Stephanie J. Loomis, M. Jensen, Saranya Duraisamy, Jason Tetrault, David Merberg, S. Badola, M. Reppell, Jason Grundstad, Xiuwen Zheng, A. Deaton, Margaret M. Parker, Lucas D. Ward, A. Flynn-Carroll, C. Austin, Ruth E. March, M. Pangalos, A. Platt, Mike Snowden, A. Matakidou, S. Wasilewski, Quanli Wang, S. Deevi, K. Carss, Katherine R Smith, Morten Søgaard, Xinli Hu, Xing Chen, Zhan Ye   +111 more
semanticscholar   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Prenatal Diagnosis and Genotype-Phenotype Correlation in 8q21.11 Microdeletion Syndrome: A Case Report

International Medical Case Reports Journal
Francesco Libotte,* Katia Margiotti,* Marco Fabiani, Alvaro Mesoraca, Claudio Giorlandino Human Genetics Lab, Altamedica Main Centre, Rome, 00198, Italy*These authors contributed equally to this workCorrespondence: Katia Margiotti,
Libotte F, Margiotti K, Fabiani M, Mesoraca A, Giorlandino C   +4 more
doaj  

Human genetics and sleep behavior

Current Opinion in Neurobiology, 2017
Why we sleep remains one of the greatest mysteries in science. In the past few years, great advances have been made to better understand this phenomenon.
Guangsen Shi, David Wu, L. Ptáček, Ying-Hui Fu   +3 more
semanticscholar   +1 more source