Results 111 to 120 of about 884,084 (316)

Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

eLife
Asthenoteratozoospermia, a prevalent cause of male infertility, lacks a well-defined etiology. DNAH12 is a special dynein featured by the absence of a microtubule-binding domain, however, its functions in spermatogenesis remain largely unknown.
Menglei Yang, Hafiz Muhammad Jafar Hussain, Manan Khan, Zubair Muhammad, Jianteng Zhou, Ao Ma, Xiongheng Huang, Jingwei Ye, Min Chen, Aoran Zhi, Tao Liu, Ranjha Khan, Ali Asim, Wasim Shah, Aurang Zeb, Nisar Ahmad, Huan Zhang, Bo Xu, Hui Ma, Qinghua Shi, Baolu Shi   +20 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Brief History of Human Genetics in Utah

Brief History of Human Genetics in Utah by Raymond F.
Raymond F. Gesteland, Ph.D.
core  

Erratum: Patenting and licensing in genetic testing: Recommendations of the European Society of Human Genetics (European Journal of Human Genetics) (2008) vol. 16 (405-411) 10.1038/sj.ejhg.5201929)

, 2008
Patents for inventions can be beneficial for society, if they drive innovation and promote progress. In most areas, the patenting system works satisfactorily.
Coviello, Domenico, Kääriäinen, Helena, Macek, Milan, Atalar, Fatmahan, Schmidtke, Joerg, Cornel, Martina, Gorry, Philippe, Tranebjaerg, Lisbeth, Cassiman, Jean Jacques, Tranebjærg, Lisbeth, Evers-Kiebooms, Gerry, Cassiman, Jean-Jacques, Anastasiadou, Violetta, Schmidtke, Jörg, van Ommen, Gert Jan, Burn, John, Hodgson, Shirley, Patch, Christine, Kosztolanyi, Gyoergy, Aymé, Ségolène, Kosztolányl, György, van Ommen, Gert-Jan, ?, ?, Braga, Suzanne, Matthijs, Gert, Sequeiros, Jorge, Stoppa-Lyonnet, Dominique, Kristoffersson, Ulf, van Heyningen, Veronica, Kosztolányi, György   +29 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Genomics and the Human Genome Project

, 2012
This OER consists of an instructional sheet produced by GENIE CETL in the Department of Genetics. By the end of this material you should have learnt about: The genome of an organism i.e.
GENIE CETL
core  

History of medical genetics in South Africa

Journal of the Colleges of Medicine of South Africa
No abstract available.
Jennifer G. Kromberg, Grietje de Jong
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Los marcadores de repetición corta en tándem como herramienta para estudios en salud pública en México

Revista de Medicina e Investigación Universidad Autónoma del Estado de México
Short tandem repeats (strs), or microsatellites, are dna sequences of 2-7 nucleotides that repeat in the human genome, besides strs allow for the study of diseases, population structure, and forensic studies.
Martin Abraham Reyes-Lara, Crystian Sadiel Venegas-Barrera, Víctor Jorge Horta-Vega, Ángel Emmanuel Villanueva-Chimal, Juan Flores-Gracia, Netzahualcoyotl Mayek-Pérez   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source