Results 131 to 140 of about 884,084 (316)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

HUMAN GENETICS [PDF]

Annual Review of Genetics, 1967
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Genomics and the Human Genome Project

, 2010
This OER consists of an instructional sheet produced by GENIE CETL in the Department of Genetics. By the end of this material you should have learnt about: The genome of an organism i.e.
GENIE CETL
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TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

, 2010
Growing evidence highlights a role for mitochondrial dysfunction and oxidative stress as underlying contributors to Parkinson's disease (PD) pathogenesis. DJ-1 (PARK7) is a recently identified recessive familial PD gene.
H. Aleyasin, Chen, C.X., MacLaurin, J.G., McBride, H.M., Aleyasin, H., I. Irrcher, Kim, R.H., Rippstein, P., M.E. Harper, Park, D. S., Fon, E.A., S.J. Hewitt, H.M. McBride, D.S. Park, Slack, R. S., Irrcher, I., L. Bevilacqua, Chhabra, S., Bevilacqua, L., P. Rippstein, Seifert, E.L., C.X. Chen, E.L. Seifert, Phillips, M., P. Rizzu, Winklhofer, K. F., McBride, H. M., Mak, T. W., M.W.C. Rousseaux, S. Callaghan, E.A. Fon, Seifert, E. L., Chen, C. X., S. Chhabra, A.K. Lutz, Rousseaux, M. W.C., MacLaurin, J. G., Fon, E. A., Jahani-Asl, A., Hewitt, S. J., Kim, R. H., Mak, T.W., Harper, M.E., R.H. Kim, Rizzu, P., Slack, R.S., T.W. Mak, Callaghan, S., Lutz, A. K., Rousseaux, M.W.C., J.G. MacLaurin, K.F. Winklhofer, A. Jahani-Asl, R.S. Slack, Lutz, A.K., Harper, M. E., Park, D.S., M. Phillips, Hewitt, S.J., Winklhofer, K.F.   +59 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

University of Utah news: Endowed chair in genetics spurs U. research program

, 1982
memorandumThis press release dated September 20, 1982, announces the University of Utah\u27s Institutional Council\u27s acceptance of a major gift providing for the Thomas D. Dee II Endowed Chair in Genetics in the Department of Human Genetics within the
University of Utah
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Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Thomas D. Dee Endowed Chair in Genetics: A proposal to Mr. Thomas D. Dee from the University School of Medicine

, 1982
memorandumThis is a copy of the University of Utah School of Medicine\u27s proposal of July, 1982 to Mr. Thomas D. Dee for a gift of $675,000.00 to an endowed chair in the then newly established Department of Human Genetics, the chair to be known as the
University of Utah
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