Results 101 to 110 of about 884,084 (316)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein

iScience
Summary: Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk.
Romina J. Bevacqua, Weichen Zhao, Emilio Merheb, Seung Hyun Kim, Alexander Marson, Anna L. Gloyn, Seung K. Kim   +6 more
doaj   +1 more source

GENETICS AND HUMAN DESTINY.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996
No Abstract.
Sinclair, Donald, Anderson, Ingram F.
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues

, 2006
The interface between assisted reproductive technologies ( ART) and genetics comprises several sensitive and important issues that affect infertile couples, families with severe genetic diseases, potential children, professionals in ART and genetics ...
Cornel, M, Cornel, Martina, Braga, S, Ibarreta, Dolores, Dolores Ibarreta, Anastasiadou, V., Tranebjaerg, Lisbeth, Evers-Kiebooms, G, Rodrigues-Cerezo, E, Geraedts, Joep, Ibarreta, D., Tranebjærg, Lisbeth, Lundin, K, Evers-Kiebooms, Gerry, Anastasiadou, Violetta, Cornel, M., Coviello, DA, Kosztolanyi, G, Jorge Sequeiros, Suzanne Braga, Domenico A Coviello, Sermon, K., Helena Kääriäinen, Rodrigues-Cerezo, E., Aymé, Ségolène, Geraedts, J, Lundin, K., Gerry Evers-Kiebooms, Karen Sermon, Sermon, Karen, Soini, S, Ségolène Aymé, Ayme, S., Sequeiros, J., Emilio Rodrigues-Cerezo, Anastasiadou, V, Kääriäinen, Helena, Harper, Joyce, Kosztolanyi, György, Soini, Sirpa, Soini, S., Lundin, Kersti, Violetta Anastasiadou, Harper, J., Sermon, K, Sequeiros, J, Evers-Kiebooms, G., Kosztolanyi, G., Rodrigues-Cerezo, Emilio, Geraedts, J., György Kosztolanyi, Luca Gianaroli, Sirpa Soini, Coviello, Domenico A., Braga, S., Kaariainen, H, Ibarreta, D, Ayme, S, Harper, J. C., Joep Geraedts, Tranebjaerg, L, Braga, Suzanne, Joyce Harper, Martina Cornel, Sequeiros, Jorge, Gianaroli, Luca, Coviello, D.A., Lisbeth Tranebjaerg, Gianaroli, L., Kersti Lundin, Gianaroli, L, Kaariainen, H.   +71 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Thoughts on Humane Genetics

Science, 2008
Davenport's Dream . 21st Century Reflections on Heredity and Eugenics. By Jan A. Witkowski and John R. Inglis, Eds. . Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2008. 520 pp. $55. ISBN 9780879697563.
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

University of Utah news: Institutional Council endorses establishing Department of Human Genetics

, 1981
memorandumThis is the University of Utah press release dated June 8, 1981 that announces the University\u27s Institutional Council\u27s approval of the creation of the Department of Human Genetics to be recommended to the Utah State Board of ...
University of Utah
core