Results 131 to 140 of about 1,291,510 (266)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Genomic language model for predicting enhancers and their allele-specific activity in the human genome. [PDF]

Bioinformatics
Sathian R, Dutta P, Ay F, Davuluri RV.
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome. [PDF]

Cell Genom
Xu Y, Loucks H, Menendez J, Ryabov F, Lucas JK, Cechova M, Morina L, Xu E, Dubocanin D, Chittenden C, Asri M, Violich I, Ortiz C, Gardner JMV, Hillaker T, O'Rourke S, McNulty B, Potapova TA, Mitchell MW, Schwartz JP, Straight AF, Gerton JL, Timp W, Alexandrov IA, Altemose N, Miga KH.   +25 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Sequencing the human genome [PDF]

Nature, 1986
J B, Walsh, J, Marks
openaire   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

P170: Leveraging a genotype-first approach in All of Us cohort to describe prevalence and phenotypic spectrum of rare genetic disorders*

Genetics in Medicine Open
Katharine Chaillet, Jonas Ladenson, Anna Noreuil, Katherine Leopold, Robert Hubley, Shannon Haines, Joshua Denny, Huan Mo, Oleg Shchelochkov   +8 more
doaj   +1 more source

Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome. [PDF]

Cell Genom
Dexheimer PJ, Hass MR, Edsall LE, Diouf AA, Jones SH, Donmez O, Yin C, Dunn KA, Forney C, Hesse HK, VonHandorf A, Chen X, Parameswaran S, Gittens OE, Viel KCMF, Razavi R, Gewurz BE, Zhao B, Lawson LP, Hughes TR, Kottyan LC, Weirauch MT.   +21 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source