Results 161 to 170 of about 2,059,789 (297)

A catalogue of early diverged contemporary human genome variation reveals distinct Khoe-San populations. [PDF]

Nat Commun
Jaratlerdsiri W, Soh PXY, Gong T, Jiang J, Simayi Z, Petersen DC, Holland E, Chan EKF, Theron KE, Haacke WHG, Förtsch HEA, Bornman MSR, Thomas DM, Mphahlele J, Hayes VM.   +14 more
europepmc   +1 more source

The human genome

Anales del Sistema Sanitario de Navarra, 2009
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Human Genome Safe Harbor Sites: A Comprehensive Review of Criteria, Discovery, Features, and Applications. [PDF]

Cells
Ahmed A, Di Molfetta D, Iaconisi GN, Caponio A, Singh A, Bibi A, Dolce V, Palmieri L, Coppola V, Fiermonte G.   +9 more
europepmc   +1 more source

Sequencing the human genome [PDF]

Nature, 1986
J B, Walsh, J, Marks
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

P170: Leveraging a genotype-first approach in All of Us cohort to describe prevalence and phenotypic spectrum of rare genetic disorders*

Genetics in Medicine Open
Katharine Chaillet, Jonas Ladenson, Anna Noreuil, Katherine Leopold, Robert Hubley, Shannon Haines, Joshua Denny, Huan Mo, Oleg Shchelochkov   +8 more
doaj   +1 more source

Public opinion survey on heritable human genome editing in South Africa: a study protocol. [PDF]

Glob Health Action
Pillay S, Thaldar D.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Verification and comparison of pig, mouse, and human genome similarities: use of manual assembly and analyses. [PDF]

BMC Genomics
Dawson HD, Chen CT, Ragonese JS, Smith AD, Lunney JK.   +4 more
europepmc   +1 more source