Results 161 to 170 of about 1,251,136 (266)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

P618: Misuse of opportunistic screening highlights shortcomings in clinical ascertainment

Genetics in Medicine Open
Julie Sapp, Leslie Biesecker, Jennifer Johnston, Katie Lewis   +3 more
doaj   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome. [PDF]

Adv Sci (Weinh)
Almassalha LM, MacQuarrie KL, Carignano M, Dunton CL, Gong R, Ibarra J, Carter LM, Li WS, Nap R, Dulai PS, Szleifer I, Backman V.   +11 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

SyMetrics: an integrated machine learning model for evaluating the pathogenicity of synonymous variants in the human genome. [PDF]

NAR Genom Bioinform
Bundalian L, Strnadová MS, Garten F, Horn S, Stenzel U, Popp D, Lemke JR, Biskup S, Schulte B, May P, Bösebeck F, Garten A, Thor D, Schulz A, Hentschel J, Kelso J, Schöneberg T, Le Duc D.   +17 more
europepmc   +1 more source

The Human Genome Project [PDF]

Journal of the Royal Society of Medicine, 2005
openaire   +2 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Identity rather than 3D position informs splicing of rare introns in the human genome. [PDF]

iScience
Springer SM, Fleck K, Girardini KN, Riccard SM, Erceg J, Kanadia RN.   +5 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Accurate human genome analysis with element avidity sequencing. [PDF]

BMC Bioinformatics
Carroll A, Kolesnikov A, Cook DE, Brambrink L, Wiseman KN, Billings SM, Kruglyak S, Lajoie BR, Zhao J, Levy SE, McLean CY, Shafin K, Nattestad M, Chang PC.   +13 more
europepmc   +1 more source