Results 171 to 180 of about 1,962,192 (329)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

The Human Genome Project [PDF]

IUBMB Life, 2001
openaire   +3 more sources

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Biosemiotics, Bioinformatics, and Responsibility: Ambivalent Consequences of the Deciphering of the Human Genome for Society and Science

, 1970
Klaus Fuchs-Kittowski, Hans-Alfred Rosenthal   +1 more
openalex   +2 more sources

Comparison of the entire genomes of bovine leukemia virus and human T-cell leukemia virus and characterization of their unidentified open reading frames. [PDF]

, 1984
Noriaki Sagata, Teruo Yasunaga, K. Ohishi, J Tsuzuku-Kawamura, Misao Onuma, Yoji Ikawa   +5 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Human polyomavirus JC virus genome

, 1984
Richard J. Frisque, G L Bream, Maria Cannella   +2 more
openalex   +1 more source

Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma [PDF]

, 1988
Yuanyuan Zhou, Betty L. Slagle, Lawrence A. Donehower, Peter vanTuinen, David H. Ledbetter, Janet S. Butel   +5 more
openalex   +1 more source

The human genome and medicine

Anales de Pediatría (English Edition), 2018
Francesc Palau, Alfredo García-Alix
openaire   +3 more sources

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source