Results 181 to 190 of about 1,210,893 (313)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Anticipatory gaps challenge the public governance of heritable human genome editing. [PDF]

J Med Ethics
Rueda J, Segers S, Hopster J, Kudlek K, Liedo B, Marchiori S, Danaher J.   +6 more
europepmc   +1 more source

MOESM13 of Genome-wide computational analysis of potential long noncoding RNA mediated DNA:DNA:RNA triplexes in the human genome

, 2017
Saakshi Jalali, Amrita Singh, Souvik Maiti, Vinod Scaria   +3 more
openalex   +1 more source

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells [PDF]

, 2016
Young Seok Ju, José M. C. Tubío, William Mifsud, Beiyuan Fu, Helen Davies, Manasa Ramakrishna, Yilong Li, Lucy Yates, Gunes Gundem, Patrick Tarpey, Sam Behjati, Elli Papaemmanuil, Sancha Martin, Anthony Fullam, Moritz Gerstung, Jyoti Nangalia, Anthony R. Green, Carlos Caldas, Åke Borg, Andrew Tutt, Ming Ta Michael Lee, Laura J. van’t Veer, Benita Kiat Tee Tan, Samuel Aparício, Paul N. Span, John W.M. Martens, Stian Knappskog, Anne Vincent‐Salomon, Anne‐Lise Børresen‐Dale, Jórunn E. Eyfjörd, Ola Myklebost, Adrienne M. Flanagan, Christopher S. Foster, David E. Neal, Colin Cooper, Rosalind A. Eeles, G. Steven Bova, Sunil R. Lakhani, Christine Desmedt, Anthony J. Gill, Andrea L. Richardson, Colin A. Purdie, Alastair M. Thompson, Ultan McDermott, Fengtang Yang, Serena Nik‐Zainal, Peter J. Campbell, Michael R. Stratton   +47 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The human genome encodes a multitude of novel miRNAs. [PDF]

Nucleic Acids Res
Gao F, Wang F, Chen Y, Deng B, Yang F, Cao H, Chen J, Chen H, Qi F, Kapranov P.   +9 more
europepmc   +1 more source

Genome-level Constraint-Based Analysis of Megasphaera sp. MJR8396C Reveals Dual Metabolic Roles in the Human Gut [PDF]

Josep Rubert, William T. Scott
openalex   +1 more source

Semiquantitative analysis of integrated genomes of human T-lymphotropic virus type I in asymptomatic virus carriers [PDF]

, 1991
Osamu Shinzato, Shigemasa Ikeda, Saburo Momita, Y Nagata, S Kamihira, E Nakayama, Hiroshi Shiku   +6 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Identification of Small Open Reading Frame-encoded Proteins in the Human Genome. [PDF]

Genomics Proteomics Bioinformatics
Kore H, Okano S, Datta KK, Thorp J, Periasamy P, Divate M, Liyanage U, Hartel G, Nagaraj SH, Gowda H.   +9 more
europepmc   +1 more source