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Illuminating the human genome

Histochemistry and Cell Biology, 2000
The identification and analysis of novel genes and their encoded protein products remains a vigorous area of research in biology today. Worldwide genomic and cDNA sequencing projects are now identifying new molecules every day and the need for methodologies to functionally characterise these proteins has never been greater.
Simpson, Jeremy C   +3 more
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Accessing the Human Genome

Current Protocols in Human Genetics, 2002
AbstractThe majority of the sequence for the human genome is now available. Regardless of the researcher's area of interest, it is quite likely that they will want to use some aspect of this data. This unit helps researchers achieve that goal. It presents the gene models available at NCBI, the UCSC Genome Browser, and Ensembl.
Deanna, Church, Kim D, Pruitt
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Sequencing the Human Genome

Science, 1997
The human genome project is at the halfway point. The genomes of 11 microbes, Escherichia coli , and yeast are finished, yet the human genome is only 2 percent finished. The scale-up to finish by 2005 presents a significant challenge.
L, Rowen, G, Mahairas, L, Hood
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Primer on the human genome

Journal of the American Academy of Dermatology, 2007
The study of the expression patterns of many genes, or even the entire genome, is now routinely possible. Such powerful tools have enabled hypothesis-generating research at a scale never before possible. Moreover, spatially or temporally linked gene and protein expression, implying co-regulation and functional relatedness, has led to the identification
Kenneth Y, Tsai, Hensin, Tsao
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The Anatomy of the Human Genome

Hospital Practice, 1980
Although perhaps only 1% of the human genome has been mapped, the clinical yield is already quite impressive. This yield includes the ability to palliate some genetic diseases pharmacologically or by environmental manipulation. We can also derive critical information on which to base decisions on termination of pregnancy.
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Targeting the human genome

Current Opinion in Biotechnology, 2006
In recent years, some useful nucleic-acid-based tools including antisense oligonucleotides, aptamers, ribozymes, and small interfering RNA have been developed to alter the expression of a given gene. To date, however, these methods have proven to be generally insufficient for many applications and typically have not demonstrated high delivery ...
Kiyoshi, Tachikawa, Steven P, Briggs
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Organization of the human genome

Journal of Inherited Metabolic Disease, 1994
SummaryThe human genome contains about 3×109 base pairs which, based on average estimates for the size of coding regions, might suggest an upper limit of about 3 million genes. Evidence from a variety of approaches indicates a much lower figure — in the range 40 000–100 000 genes.
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Human Genome Project

The American Journal of Surgery, 1993
The Human Genome Project is an international effort to clone and sequence the entire human genome. This audacious undertaking, estimated to cost 200 million dollars per year and require 15 years to complete, promises to be one of the most revolutionary and captivating scientific endeavors ever conceived by mankind.
M P, Sawicki   +3 more
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The Human Genome Project

2011
Charles Robert Darwin, author of On the Origin of Species, was born on 12 February 1809, which was why so much attention was paid to the creator of the evolution theory in 2009, and why that year was designated the International Year of Darwin. It was also a good excuse for supporters of Darwin, for creationists (people who believe in the biblical ...
Johannes Tramper, Yang Zhu
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Plumbing the human genome

The Lancet Oncology, 2000
Even the best and brightest minds have their weaknesses. As a senior British civil servant once observed, the human brain is a remarkable organ, “It begins working the moment you are born and never stops until you stand up to speak in public”. But, unless you are a politician or a sports commentator, at least spoken gaffes are quickly forgotten.
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