Results 31 to 40 of about 908,738 (290)

Race: How the Post-Genomic Era Has Unmasked a Misconception Promoted by Healthcare

Medicina, 2023
The term “race” has been employed to categorize human beings into distinct groups based on some perceived biological distinctions. This concept was debunked with the completion of the Human Genome Project and its revolutionary findings that all humans ...
Donna Schaare, Ludovico Abenavoli, Luigi Boccuto   +2 more
doaj   +1 more source

Anaplastic thyroid cancer: genome-based search for new targeted therapy options

Endocrine Connections, 2022
Objective: Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers with meager treatment options. We aimed to identify the targeted drugs already approved by the Food and Drug Administration (FDA) for solid cancer in general, which could ...
Daniel Alexander Hescheler, Milan Janis Michael Hartmann, Burkhard Riemann, Maximilian Michel, Christiane Josephine Bruns, Hakan Alakus, Costanza Chiapponi   +6 more
doaj   +1 more source

EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis

Neoplasia: An International Journal for Oncology Research, 2017
BACKGROUND & AIM: p53 activation by cellular stresses induces the transcription of hundreds of its target genes. To elucidate the entire picture of its downstream pathway, we screened a cDNA microarray dataset of adriamycin-treated HCT116 p53−/− or p53+/+
Jinichi Mori, Chizu Tanikawa, Naomi Ohnishi, Yuki Funauchi, Osamu Toyoshima, Koji Ueda, Koichi Matsuda   +6 more
doaj   +1 more source

Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population

Frontiers in Immunology, 2023
Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex.
Seik-Soon Khor, Kazuko Ueno, Nao Nishida, Nao Nishida, Minae Kawashima, Yosuke Kawai, Yoshihiro Aiba, Yuki Hitomi, Masao Nagasaki, Masao Nagasaki, Minoru Nakamura, Minoru Nakamura, Minoru Nakamura, Katsushi Tokunaga   +13 more
doaj   +1 more source

Gene editing using gamma modified PNA: HBB gene as a model

Journal of Genetic Engineering and Biotechnology
PNAs have emerged as a powerful tool in gene editing, particularly for correcting monogenic disorders by enhancing targeted recombination and genomic modifications.
Noha Eltaweel, Ghada Elkamah, Nesma Elaraby, Iman Hassan, Ahmed Wassel, Nahla Abdel-Aziz, Khalda Amr   +6 more
doaj   +1 more source

Discovery and genotyping of structural variation from long-read haploid genome sequence data [PDF]

, 2016
In an effort to more fully understand the full spectrum of human genetic variation, we generated deep single-molecule, real-time (SMRT) sequencing data from two haploid human genomes.
Boitano, Matthew, Chaisson, Mark J.P., Chin, Chen-Shin, Eichler, Evan E, Gordon, David, Graves-Lindsay, Tina A, Hoekzema, Kendra, Huddleston, John, Korlach, Jonas, Kronenberg, Zev N, Munson, Katherine M, Peluso, Paul, Steinberg, Karyn Meltz, Vives, Laura, Warren, Wes, Wilson, Richard K   +15 more
core   +2 more sources

The human genome sequencing race ended 20 years ago [PDF]

The Ukrainian Biochemical Journal, 2020
The Human Genome Project, one of the most grandiose in contemporary science, was officially launched in 1990. The project aimed at determining the human DNA primary structure and gene localization and functions as well as ensuring free access of ...
M. V. Grigorieva, S. V. Komisarenko
doaj   +1 more source

The human genome project aims for 2003 [PDF]

, 1998
Bold is the operative word for the goals in the new five-year plan for the U.S. Human Genome Project as presented at the National Human Genome Research Institute (NHGRI) advisory council meeting on September 14, 1998.
Goodman, L.
core   +1 more source

Origins of the Human Genome Project [PDF]

, 1994
Dr. Cook-Deegan recounts some of the scientific and political history leading to controversy about the proper mix of private and public roles in pursuing genome research and bringing its fruits to bear, e.g., in preventing and curing ...
Cook-Deegan, Robert Mullan
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source