Results 51 to 60 of about 13,494,204 (297)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads [PDF]

, 2021
Human genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and scaffolding ...
Sorensen, Melanie, Ebler, Jana, Marijon, P., Ebert, Peter, Sanders, A.D., Pierre Marijon, Mitchell R. Vollger, Korbel, J., Marijon, Pierre, Paten, B., Harvey, W.T., Melanie Sorensen, Benedict Paten, Ashley D. Sanders, Marschall, T., Sulovari, A., Haukness, Marina, Lee, Charles, Maryam Ghareghani, Audano, P., Peter A. Audano, Scott E. Devine, Structural Variation Consortium, Human Genome, Ebert, P., Marschall, Tobias, Paten, Benedict, Katherine M. Munson, Ebler, J., Harvey, W., Peter Ebert, Lansdorp, P., David Porubsky, Jan O. Korbel, Chaisson, Mark J P, Haukness, M., William T. Harvey, Eichler, E.E., Arvis Sulovari, Eichler, E., Chaisson, M.J.P., Chaisson, M., Vollger, Mitchell R, Vollger, M.R., Sanders, Ashley D, Evan E. Eichler, Ghareghani, M., Harvey, William T, Tobias Marschall, Jana Ebler, Peter M. Lansdorp, Mark J. P. Chaisson, Devine, Scott E, Lansdorp, P.M., Sanders, A., Audano, P.A., Eichler, Evan E, Porubsky, D., Sulovari, Arvis, Devine, S.E., Devine, S., Ghareghani, Maryam, Porubsky, David, Munson, K.M., Vollger, M., Sorensen, M., Audano, Peter A, Charles Lee, Lansdorp, Peter M, Munson, Katherine M, Munson, K., Korbel, J.O., Marina Haukness, Korbel, Jan O, Lee, C.   +73 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Genomics and the human genome project: implications for psychiatry [PDF]

International Review of Psychiatry, 2004
In the past decade the Human Genome Project has made extraordinary strides in understanding of fundamental human genetics. The complete human genetic sequence has been determined, and the chromosomal location of almost all human genes identified. Presently, a large international consortium, the HapMap Project, is working to identify a large portion of ...
openaire   +3 more sources

Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution [PDF]

, 2005
For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their DNA content rather than solely ...
Wienberg, Johannes, Wienberg, J.
core   +1 more source

Discovery of "Nobody", a Microprotein, Versus Human Genome Project

Journal of Nobel Medical College, 2017
Not available. Journal of Nobel Medical College Volume 6, Number 1, Issue 10 (January-June, 2017).
Arambam Giridhari Singh
doaj   +1 more source