Results 31 to 40 of about 13,494,204 (297)
Gene editing using gamma modified PNA: HBB gene as a model
Journal of Genetic Engineering and BiotechnologyPNAs have emerged as a powerful tool in gene editing, particularly for correcting monogenic disorders by enhancing targeted recombination and genomic modifications.
Noha Eltaweel +6 more
doaj +1 more source
Origins of the human genome project [PDF]
The FASEB Journal, 1991 The Human Genome Project has become a reality. Building on a debate that dates back to 1985, several genome projects are now in full stride around the world, and more are likely to form in the next several years. Italy began its genome program in 1987, and the United Kingdom and U.S.S.R in 1988.
J D, Watson, R M, Cook-Deegan
openaire +2 more sources
Frontiers in Immunology, 2023 Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex.
Seik-Soon Khor +13 more
doaj +1 more source
The human genome sequencing race ended 20 years ago [PDF]
The Ukrainian Biochemical Journal, 2020 The Human Genome Project, one of the most grandiose in contemporary science, was officially launched in 1990. The project aimed at determining the human DNA primary structure and gene localization and functions as well as ensuring free access of ...
M. V. Grigorieva, S. V. Komisarenko
doaj +1 more source
, 2021 International and collaborative project to sequence the entire genome of human species, (names of International institutes and researchers involved)
gaurika loomba
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples. [PDF]
PLoS Computational Biology, 2013 There are 10× more bacterial cells in our bodies from the microbiome than human cells. Viral DNA is known to integrate in the human genome, but the integration of bacterial DNA has not been described. Using publicly available sequence data from the human
David R Riley +6 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Life in our hands? Some ethical perspectives on the human genome and human genome diversity projects
Verbum et Ecclesia, 2014 The article dealt with implications of the human genome and the human genome diversity project. It examined some theological implications, such as: humans as the image of God, God as the creator of life, the changed role of miracles and healings in ...
Cornelius W. du Toit
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source