Results 61 to 70 of about 549,507 (300)

Justice and the human genome project

, 1994
The Human Genome Project is an expensive, ambitious, and controversial attempt to locate and map every one of the approximately 100,000 genes in the human body.
Murphy, Timothy F 1955-, Lappé, Marc, Human Genome Project., Human Genome Project   +3 more
core  

Functional analysis and transcriptional output of the Göttingen minipig genome [PDF]

, 2015
In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism.
Isaac Lekolool (3417695), Ulrich Certa, Martin Ebeling (187407), Okoth, Edward, Ringshandl, Stephan, Bernd Kuhn (260084), Schmitt, Georg, Daubenberger, Claudia, Roger Pelle, Azinwi Phina Khan, Küng, Erich, Hamina Daff (2139655), Guido Steiner (72571), Lekolool, Isaac, Marco Berrera (82653), Erich Küng, Heckel, Tobias, Edward Okoth, Berrera, Marco, Khan, Azinwi Phina, Hamina Daff, Laura Badi (187411), Ulrich Certa (54734), Ebeling, Martin, Roland Schmucki (793618), Edward Okoth (734350), Stephan Ringshandl (3417686), Schmucki, Roland, Daff, Hamina, Certa, Ulrich, Nicole Kratochwil (2463565), Kiialainen, Anna, Claudia Daubenberger, Tobias Heckel (3417707), Bernd Kuhn, Richard Bishop (59737), Roger Pelle (59739), Richard Bishop, Anna Kiialainen, Morgane Ravon (3417692), Tobias Heckel, Corinne Nowaczyk (3417704), Steiner, Guido, Nicole A. Kratochwil, Georg Schmitt, Laura Badi, Georg Schmitt (3417689), Marco Berrera, Morgane Ravon, Anna Kiialainen (230525), Pelle, Roger, Nowaczyk, Corinne, Corinne Nowaczyk, Stephan Ringshandl, Erich KĂźng (3417734), Claudia Daubenberger (212658), Kratochwil, Nicole A., Guido Steiner, Ravon, Morgane, Bishop, Richard, Martin Ebeling, Azinwi Khan (3417698), Badi, Laura, Roland Schmucki, Isaac Lekolool, Kuhn, Bernd   +65 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Human microbiome, applied to clinical practice

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
The aim of review. The Human microbiome project was designed for identification and characterization of set of human microorganisms as well as for studying the changes in the human health due to microbiome changes.
V. T. Ivashkin, K. V. Ivashkin
doaj   +1 more source

Initial Genomics of the Human Nucleolus [PDF]

, 2010
We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different ...
Laengst, Gernot, Santoyo-Lopez, Javier, Bálint Péterfia, Montaner David, Längst, Gernot, Conesa, Ana, Javier Santoyo-Lopez, Irina Solovei, Solovei, Irina, Dopazo, Joaquin, Cremer Thomas, Thomas Cremer, Joaquin Dopazo, Ignacio Medina, Nemeth, Attila, Medina, Ignacio, Längst Gernot, Akhtar, Asifa, Medina Ignacio, Németh Attila, Peterfia, Balint, Gernot Längst, Cremer, Thomas, Péterfia Bálint, Montaner, David, Solovei Irina, Attila Németh, Ana Conesa, Santoyo-Lopez Javier, Dopazo Joaquin, Conesa Ana, David Montaner   +31 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A novel NODAL variant in a young embolic stroke patient with visceral heterotaxy

BMC Neurology
Background Ischemic stroke in young adults can be caused by a variety of etiologies including the monogenic disorders. Visceral heterotaxy is a condition caused by abnormal left–right determinations during embryonic development. We aimed to determine the
Kei Kaburagi, Yuta Hagiwara, Keiji Tachikawa, Noriko Miyake, Hisanao Akiyama, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, Yoshihisa Yamano, Takahiro Shimizu, Satomi Mitsuhashi   +10 more
doaj   +1 more source

Entrepreneurial Experiments in Science Policy: Analizing the Human Genome Project [PDF]

We re-conceptualize the role of science policy makers, envisioning and illustrating their move from being simple investors in scientific projects to entrepreneurs who create the conditions for entrepreneurial experiments and initiate them.
Fiona E. Murray, Kenneth G. Huang
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Genomics and the Human Genome Project

, 2012
This OER consists of an instructional sheet produced by GENIE CETL in the Department of Genetics. By the end of this material you should have learnt about: The genome of an organism i.e.
GENIE CETL
core