Results 221 to 230 of about 12,521,599 (286)

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

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Human Growth Hormone

American Journal of Diseases of Children, 1974
As recalled by Dr. Wilhelmi, it is now 30 years since Li, Evans, and Simpson conclusively demonstrated the existence of growth hormone (GH). Now, GH has an established place in the promotion of growth and the regulation of energy metabolism. In 1957 Daughaday discovered a serum factor ("sulfation factor" or somatomedin [SM]) that, under the influence ...
N K, Maclaren, M, CORNBLATH, S, Raiti
openaire   +2 more sources

Antibodies to human growth hormone developing during therapy with human growth hormone

The Journal of Pediatrics, 1965
THE DETECTION of antibodies to human growth hormone (HGH) developing during long-term therapy with HGH has recently been reported by several investigators. Antibodies did not appear to interfere with the response to HGH in two patients reported by Trafford et al1or in three patients reported by Roth et al.2The growth-promoting effect appeared to be ...
S D, Frasier, F G, Smith
openaire   +2 more sources

Human Growth Hormone

Nature, 1972
Human growth hormone is a successful treatment for children who without it would grow up to be midgets. This article describes present knowledge of its physiology, its role in the regulation of growth and its effect in treatment.
openaire   +3 more sources

Human Growth Hormone and Human Aging

Endocrine Reviews, 1993
In humans, both aging and GH deficiency are associated with reduced protein synthesis, decreased lean body and bone mass, and increased percent body fat. In healthy individuals, spontaneous and stimulated GH secretion, as well as circulating IGF-I and IGFBP-3 levels, are significantly decreased with advancing age.
E, Corpas, S M, Harman, M R, Blackman
openaire   +2 more sources